ENSG00000220205


Homo sapiens

Features
Gene ID: ENSG00000220205
  
Biological name :VAMP2
  
Synonyms : P63027 / VAMP2 / vesicle associated membrane protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 8159149
Gene end: 8163546
  
Corresponding Affymetrix probe sets: 201556_s_at (Human Genome U133 Plus 2.0 Array)   201557_at (Human Genome U133 Plus 2.0 Array)   214792_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000314214
Ensembl peptide - ENSP00000418572
Ensembl peptide - ENSP00000466995
Ensembl peptide - ENSP00000467399
NCBI entrez gene - 6844     See in Manteia.
OMIM - 185881
RefSeq - XM_005256775
RefSeq - NM_014232
RefSeq Peptide - NP_001317054
RefSeq Peptide - NP_055047
swissprot - K7ENK9
swissprot - F8WCA0
swissprot - P63027
swissprot - J3QRU4
Ensembl - ENSG00000220205
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Vamp2ENSMUSG00000020894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC129492.3ENSG0000026362093
VAMP1 / P23763 / vesicle associated membrane protein 1ENSG0000013919077
VAMP3 / Q15836 / vesicle associated membrane protein 3ENSG0000004924563
VAMP4 / O75379 / vesicle associated membrane protein 4ENSG0000011753332
VAMP8 / Q9BV40 / vesicle associated membrane protein 8ENSG0000011864028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein
 IPR028717  Vesicle-associated membrane protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0006892 post-Golgi vesicle-mediated transport TAS
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0009749 response to glucose ISS
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0015031 protein transport ISS
 biological_processGO:0016079 synaptic vesicle exocytosis TAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis ISS
 biological_processGO:0017157 regulation of exocytosis ISS
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0043001 Golgi to plasma membrane protein transport ISS
 biological_processGO:0043308 eosinophil degranulation IMP
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0060627 regulation of vesicle-mediated transport ISS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061025 membrane fusion ISS
 biological_processGO:0065003 protein-containing complex assembly ISS
 biological_processGO:0090316 positive regulation of intracellular protein transport ISS
 biological_processGO:1902259 regulation of delayed rectifier potassium channel activity ISS
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030141 secretory granule ISS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030672 synaptic vesicle membrane ISS
 cellular_componentGO:0031201 SNARE complex TAS
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042589 zymogen granule membrane ISS
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 cellular_componentGO:0044306 neuron projection terminus ISS
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0060203 clathrin-sculpted glutamate transport vesicle membrane TAS
 cellular_componentGO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
 cellular_componentGO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISS
 cellular_componentGO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISS
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070083 clathrin-sculpted monoamine transport vesicle membrane TAS
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0017075 syntaxin-1 binding ISS
 molecular_functionGO:0019905 syntaxin binding ISS
 molecular_functionGO:0043621 protein self-association TAS
 molecular_functionGO:0048306 calcium-dependent protein binding ISS


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Insulin processing
Clathrin derived vesicle budding
Regulation of insulin secretion
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Other interleukin signaling
Toxicity of botulinum toxin type D (BoNT/D)
Toxicity of botulinum toxin type B (BoNT/B)
Toxicity of botulinum toxin type F (BoNT/F)
Toxicity of tetanus toxin (TeNT)
Toxicity of botulinum toxin type G (BoNT/G)
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106089 STX1A / Q16623 / syntaxin 1A  / complex
 ENSG00000092531 O00161 / SNAP23 / synaptosome associated protein 23  / complex / reaction
 ENSG00000067715 SYT1 / P21579 / synaptotagmin 1  / complex
 ENSG00000103496 STX4 / Q12846 / syntaxin 4  / reaction / complex
 ENSG00000073921 PICALM / Q13492 / phosphatidylinositol binding clathrin assembly protein  / complex / reaction
 ENSG00000104888 Q9P2U7 / SLC17A7 / solute carrier family 17 member 7  / complex
 ENSG00000187714 Q16572 / SLC18A3 / solute carrier family 18 member A3  / complex / reaction
 ENSG00000105649 RAB3A / P20336 / RAB3A, member RAS oncogene family  / complex
 ENSG00000132639 P60880 / SNAP25 / synaptosome associated protein 25  / complex






 

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contact: otassy@igbmc.fr