ENSG00000117533


Homo sapiens

Features
Gene ID: ENSG00000117533
  
Biological name :VAMP4
  
Synonyms : O75379 / VAMP4 / vesicle associated membrane protein 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.3
Gene start: 171700160
Gene end: 171742247
  
Corresponding Affymetrix probe sets: 207350_s_at (Human Genome U133 Plus 2.0 Array)   211760_s_at (Human Genome U133 Plus 2.0 Array)   213480_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000236192
Ensembl peptide - ENSP00000356714
Ensembl peptide - ENSP00000435933
NCBI entrez gene - 8674     See in Manteia.
OMIM - 606909
RefSeq - XM_017002713
RefSeq - NM_001185127
RefSeq - NM_003762
RefSeq Peptide - NP_003753
RefSeq Peptide - NP_001172056
swissprot - O75379
swissprot - Q6IAZ3
Ensembl - ENSG00000117533
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vamp4ENSDARG00000043510Danio rerio
 VAMP4ENSGALG00000031381Gallus gallus
 Vamp4ENSMUSG00000026696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAMP2 / P63027 / vesicle associated membrane protein 2ENSG0000022020527
AC129492.3ENSG0000026362026
VAMP1 / P23763 / vesicle associated membrane protein 1ENSG0000013919025
VAMP3 / Q15836 / vesicle associated membrane protein 3ENSG0000004924523
VAMP8 / Q9BV40 / vesicle associated membrane protein 8ENSG0000011864018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0006887 exocytosis IBA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035493 SNARE complex assembly IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0090161 Golgi ribbon formation IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000073969 NSF / P46459 / N-ethylmaleimide sensitive factor, vesicle fusing ATPase  / complex / reaction
 ENSG00000105402 NAPA / P54920 / NSF attachment protein alpha  / complex / reaction
 ENSG00000135823 STX6 / O43752 / syntaxin 6  / complex
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / complex
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / complex






 

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