ENSG00000105402


Homo sapiens

Features
Gene ID: ENSG00000105402
  
Biological name :NAPA
  
Synonyms : NAPA / NSF attachment protein alpha / P54920
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 47487637
Gene end: 47515240
  
Corresponding Affymetrix probe sets: 206491_s_at (Human Genome U133 Plus 2.0 Array)   208751_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472235
Ensembl peptide - ENSP00000471520
Ensembl peptide - ENSP00000472667
Ensembl peptide - ENSP00000263354
Ensembl peptide - ENSP00000470654
Ensembl peptide - ENSP00000470665
Ensembl peptide - ENSP00000470946
Ensembl peptide - ENSP00000470954
Ensembl peptide - ENSP00000471018
Ensembl peptide - ENSP00000471261
NCBI entrez gene - 8775     See in Manteia.
OMIM - 603215
RefSeq - XM_011527437
RefSeq - NM_003827
RefSeq - XM_011527436
RefSeq Peptide - NP_003818
swissprot - M0R031
swissprot - M0R058
swissprot - M0R0I4
swissprot - M0R0Y2
swissprot - M0R213
swissprot - M0R2M1
swissprot - A0A024R0R9
swissprot - P54920
swissprot - M0QZM9
swissprot - M0R027
swissprot - M0QZN5
Ensembl - ENSG00000105402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 napaaENSDARG00000067605Danio rerio
 napabENSDARG00000020405Danio rerio
 NapaENSMUSG00000006024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NAPB / Q9H115 / NSF attachment protein betaENSG0000012581483


Protein motifs (from Interpro)
Interpro ID Name
 IPR000744  NSF attachment protein
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0006891 intra-Golgi vesicle-mediated transport TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010807 regulation of synaptic vesicle priming IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0032984 protein-containing complex disassembly IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035494 SNARE complex disassembly IBA
 biological_processGO:0045176 apical protein localization IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0061025 membrane fusion TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005774 vacuolar membrane IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0005483 soluble NSF attachment protein activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Golgi Associated Vesicle Biogenesis
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / reaction / complex
 ENSG00000135823 STX6 / O43752 / syntaxin 6  / reaction / complex
 ENSG00000106636 YKT6 / O15498 / YKT6 v-SNARE homolog  / complex / reaction
 ENSG00000053501 USE1 / Q9NZ43 / unconventional SNARE in the ER 1  / complex / reaction
 ENSG00000108587 GOSR1 / O95249 / golgi SNAP receptor complex member 1  / complex / reaction
 ENSG00000049245 VAMP3 / Q15836 / vesicle associated membrane protein 3  / complex / reaction
 ENSG00000117533 VAMP4 / O75379 / vesicle associated membrane protein 4  / complex / reaction
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / reaction / complex
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / complex / reaction
 ENSG00000108433 GOSR2 / O14653 / golgi SNAP receptor complex member 2  / reaction / complex
 ENSG00000162236 STX5 / Q13190 / syntaxin 5  / reaction / complex
 ENSG00000113734 BNIP1 / Q12981 / BCL2 interacting protein 1  / complex / reaction
 ENSG00000177951 BET1L / Q9NYM9 / Bet1 golgi vesicular membrane trafficking protein like  / reaction / complex
 ENSG00000092108 SCFD1 / Q8WVM8 / sec1 family domain containing 1  / reaction / complex
 ENSG00000168818 STX18 / Q9P2W9 / syntaxin 18  / complex / reaction
 ENSG00000105402 NAPA / P54920 / NSF attachment protein alpha  / complex / reaction
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / reaction / complex
 ENSG00000105829 BET1 / O15155 / Bet1 golgi vesicular membrane trafficking protein  / reaction / complex
 ENSG00000073969 NSF / P46459 / N-ethylmaleimide sensitive factor, vesicle fusing ATPase  / reaction / complex






 

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