ENSMUSG00000006024


Mus musculus

Features
Gene ID: ENSMUSG00000006024
  
Biological name :Napa
  
Synonyms : Alpha-soluble NSF attachment protein / Napa / Q9DB05
  
Possible biological names infered from orthology : NSF attachment protein alpha / P54920
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16098458
Gene end: 16117975
  
Corresponding Affymetrix probe sets: 10550237 (MoGene1.0st)   1416192_at (Mouse Genome 430 2.0 Array)   1448243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147358
Ensembl peptide - ENSMUSP00000006181
NCBI entrez gene - 108124     See in Manteia.
MGI - MGI:104563
RefSeq - NM_025898
RefSeq Peptide - NP_080174
swissprot - A0A1B0GR35
swissprot - Q9DB05
Ensembl - ENSMUSG00000006024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 napaaENSDARG00000067605Danio rerio
 napabENSDARG00000020405Danio rerio
 NAPAENSG00000105402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Napb / P28663 / Beta-soluble NSF attachment protein / Q9H115* / NSF attachment protein beta*ENSMUSG0000002743883


Protein motifs (from Interpro)
Interpro ID Name
 IPR000744  NSF attachment protein
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0010807 regulation of synaptic vesicle priming IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0032984 protein-containing complex disassembly IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IGI
 biological_processGO:0035494 SNARE complex disassembly IGI
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0061025 membrane fusion IBA
 cellular_componentGO:0005774 vacuolar membrane IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005483 soluble NSF attachment protein activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Golgi Associated Vesicle Biogenesis
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002200 abnormal brain ventricle/choroid plexus morphology "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0009688 abnormal spinal cord central canal morphology "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0010151 abnormal spinal cord ependymal layer morphology "any structural anomaly of the cellular membrane that lines the central canal of the spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: KitW-19H/Kit+
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002741 Ykt6 / Q9CQW1 / YKT6 v-SNARE homolog (S. cerevisiae) / O15498* / YKT6 v-SNARE homolog*  / complex / reaction
 ENSMUSG00000032757 Bet1 / O35623 / BET1 homolog / O15155* / Bet1 golgi vesicular membrane trafficking protein*  / complex / reaction
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / reaction / complex
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / reaction / complex
 ENSMUSG00000025484 Bet1l / O35153 / BET1-like protein / Q9NYM9* / Bet1 golgi vesicular membrane trafficking protein like*  / reaction / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / reaction / complex
 ENSMUSG00000027522 Stx16 / Q8BVI5 / syntaxin 16 / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / complex / reaction
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / complex / reaction
 ENSMUSG00000024983 Vti1a / O89116 / vesicle transport through interaction with t-SNAREs 1A / Q96AJ9*  / reaction / complex
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / complex / reaction
 ENSMUSG00000026470 Stx6 / Q9JKK1 / Syntaxin-6 / O43752*  / reaction / complex
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / reaction / complex
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / complex / reaction
 ENSMUSG00000010392 Gosr1 / O88630 / golgi SNAP receptor complex member 1 / O95249*  / complex / reaction
 ENSMUSG00000026696 Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*  / complex / reaction
 ENSMUSG00000020952 Scfd1 / Q8BRF7 / Sec1 family domain-containing protein 1 / Q8WVM8* / sec1 family domain containing 1*  / complex / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction / complex






 

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