ENSMUSG00000029125


Mus musculus

Features
Gene ID: ENSMUSG00000029125
  
Biological name :Stx18
  
Synonyms : Q8VDS8 / Stx18 / Syntaxin-18
  
Possible biological names infered from orthology : Q9P2W9
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B3
Gene start: 38038742
Gene end: 38137765
  
Corresponding Affymetrix probe sets: 10521543 (MoGene1.0st)   1425011_x_at (Mouse Genome 430 2.0 Array)   1429288_x_at (Mouse Genome 430 2.0 Array)   1431295_a_at (Mouse Genome 430 2.0 Array)   1435102_a_at (Mouse Genome 430 2.0 Array)   1443734_at (Mouse Genome 430 2.0 Array)   1453819_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143909
Ensembl peptide - ENSMUSP00000109761
Ensembl peptide - ENSMUSP00000144088
Ensembl peptide - ENSMUSP00000118218
Ensembl peptide - ENSMUSP00000031008
Ensembl peptide - ENSMUSP00000038205
NCBI entrez gene - 71116     See in Manteia.
MGI - MGI:1918366
RefSeq - NM_026959
RefSeq - XM_006504112
RefSeq - XM_006504111
RefSeq - NM_001289535
RefSeq - NM_001289536
RefSeq Peptide - NP_001276464
RefSeq Peptide - NP_001276465
RefSeq Peptide - NP_081235
swissprot - A0A0J9YUA5
swissprot - Q8VDS8
swissprot - D3YY98
swissprot - A0A0J9YTY5
Ensembl - ENSMUSG00000029125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx18ENSDARG00000035763Danio rerio
 STX18ENSGALG00000015012Gallus gallus
 STX18ENSG00000168818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR019529  SNARE-complex protein Syntaxin-18, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IBA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:0090158 endoplasmic reticulum membrane organization ISO
 biological_processGO:1902117 positive regulation of organelle assembly ISO
 biological_processGO:1902953 positive regulation of ER to Golgi vesicle-mediated transport ISO
 biological_processGO:1903358 regulation of Golgi organization ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031201 SNARE complex IBA
 molecular_functionGO:0005484 SNAP receptor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / reaction / complex
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / complex
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / complex
 ENSMUSG00000028999 Rint1 / Q8BZ36 / RAD50 interactor 1 / Q6NUQ1*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / reaction / complex
 ENSMUSG00000032264 Zw10 / O54692 / zw10 kinetochore protein / O43264*  / reaction
 ENSMUSG00000020576 Nbas / neuroblastoma amplified sequence / A2RRP1*  / reaction






 

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