ENSMUSG00000034187


Mus musculus

Features
Gene ID: ENSMUSG00000034187
  
Biological name :Nsf
  
Synonyms : Nsf / P46460 / Vesicle-fusing ATPase
  
Possible biological names infered from orthology : N-ethylmaleimide sensitive factor, vesicle fusing ATPase / P46459
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 103821782
Gene end: 103954056
  
Corresponding Affymetrix probe sets: 10391963 (MoGene1.0st)   1422455_s_at (Mouse Genome 430 2.0 Array)   1422456_at (Mouse Genome 430 2.0 Array)   1430409_at (Mouse Genome 430 2.0 Array)   1457205_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133603
Ensembl peptide - ENSMUSP00000099364
Ensembl peptide - ENSMUSP00000133591
NCBI entrez gene - 18195     See in Manteia.
MGI - MGI:104560
RefSeq - NM_008740
RefSeq Peptide - NP_032766
swissprot - P46460
swissprot - G3UX86
swissprot - G3UX98
Ensembl - ENSMUSG00000034187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsfaENSDARG00000007654Danio rerio
 nsfbENSDARG00000038991Danio rerio
 NSFENSGALG00000001055Gallus gallus
 NSFENSG00000073969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035494 SNARE complex disassembly ISS
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0017075 syntaxin-1 binding IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019905 syntaxin binding IDA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled IMP
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Trafficking of GluR2-containing AMPA receptors
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002741 Ykt6 / Q9CQW1 / YKT6 v-SNARE homolog (S. cerevisiae) / O15498* / YKT6 v-SNARE homolog*  / complex / reaction
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / reaction / complex
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / complex / reaction
 ENSMUSG00000010392 Gosr1 / O88630 / golgi SNAP receptor complex member 1 / O95249*  / reaction / complex
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / reaction / complex
 ENSMUSG00000020952 Scfd1 / Q8BRF7 / Sec1 family domain-containing protein 1 / Q8WVM8* / sec1 family domain containing 1*  / complex / reaction
 ENSMUSG00000025484 Bet1l / O35153 / BET1-like protein / Q9NYM9* / Bet1 golgi vesicular membrane trafficking protein like*  / complex / reaction
 ENSMUSG00000026470 Stx6 / Q9JKK1 / Syntaxin-6 / O43752*  / reaction / complex
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / complex / reaction
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / reaction / complex
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction / complex
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex
 ENSMUSG00000027522 Stx16 / Q8BVI5 / syntaxin 16 / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / complex / reaction
 ENSMUSG00000024983 Vti1a / O89116 / vesicle transport through interaction with t-SNAREs 1A / Q96AJ9*  / reaction / complex
 ENSMUSG00000032757 Bet1 / O35623 / BET1 homolog / O15155* / Bet1 golgi vesicular membrane trafficking protein*  / reaction / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / reaction / complex
 ENSMUSG00000026696 Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*  / reaction / complex






 

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