ENSDARG00000007654


Danio rerio

Features
Gene ID: ENSDARG00000007654
  
Biological name :nsfa
  
Synonyms : N-ethylmaleimide-sensitive factor a / nsfa
  
Possible biological names infered from orthology : N-ethylmaleimide sensitive factor, vesicle fusing ATPase / NSF / P46459 / P46460 / Vesicle-fusing ATPase
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 34766989
Gene end: 34801041
  
Corresponding Affymetrix probe sets: Dr.9155.1.S1_at (Zebrafish Array)   Dr.9155.2.A1_at (Zebrafish Array)   NM_001044328_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000093817
NCBI entrez gene - 368483     See in Manteia.
RefSeq - NM_001044328
RefSeq Peptide - NP_001037793
swissprot - B7ZV62
ZFIN ID - ZDB-GENE-030616-37
Ensembl - ENSDARG00000007654
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NSFENSGALG00000001055Gallus gallus
 NSFENSG00000073969Homo sapiens
 NsfENSMUSG00000034187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nsfb / N-ethylmaleimide-sensitive factor b / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*ENSDARG0000003899182


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0045162 clustering of voltage-gated sodium channels IMP
 biological_processGO:0048592 eye morphogenesis IMP
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0048914 myelination of anterior lateral line nerve axons IMP
 biological_processGO:0048929 efferent axon development in posterior lateral line nerve IMP
 biological_processGO:0048932 myelination of posterior lateral line nerve axons IMP
 biological_processGO:0048933 afferent axon development in posterior lateral line nerve IMP
 biological_processGO:0051875 pigment granule localization IMP
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Trafficking of GluR2-containing AMPA receptors
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder collapsed , abnormal
Show

 ZFA:0000152 retina retina apoptotic process increased occurrence , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0001094 whole organism whole organism immobile , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism increased length , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon degenerate , abnormal
Show

 ZFA:0009091 melanocyte melanocyte dispersed , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell apoptotic , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000034885 bet1 / Bet1 golgi vesicular membrane trafficking protein / O15155* / O35623* / BET1 homolog *  / reaction / complex
 ENSDARG00000020405 napab / N-ethylmaleimide-sensitive factor attachment protein, alpha b / NAPA* / Q9DB05* / P54920* / NSF attachment protein alpha* / Alpha-soluble NSF attachment protein *  / reaction / complex
 ENSDARG00000025033 stx5a / syntaxin 5A / STX5* / Q8K1E0* / Q13190* / syntaxin 5*  / reaction / complex
 ENSDARG00000035763 stx18 / Q4VBI7 / syntaxin 18 / Q9P2W9*  / complex / reaction
 ENSDARG00000032037 bet1l / Q68EL3 / Bet1 golgi vesicular membrane trafficking protein-like / Q9NYM9* / O35153* / Gm45785* / BET1-like protein *  / complex / reaction
 ENSDARG00000038991 nsfb / N-ethylmaleimide-sensitive factor b / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex
 ENSDARG00000053070 gosr2 / golgi SNAP receptor complex member 2 / O14653* / O35166* / AC005670.2*  / complex / reaction
 ENSDARG00000043510 vamp4 / vesicle-associated membrane protein 4 / O70480* / O75379*  / complex / reaction
 ENSDARG00000026654 gosr1 / golgi SNAP receptor complex member 1 / O88630* / O95249*  / reaction / complex
 ENSDARG00000007654 nsfa / N-ethylmaleimide-sensitive factor a / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex
 ENSDARG00000070161 vamp3 / vesicle-associated membrane protein 3 (cellubrevin) / P63024* / Q15836* / vesicle associated membrane protein 3*  / reaction / complex
 ENSDARG00000003307 stx16 / syntaxin 16 / Q8BVI5* / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / reaction / complex
 ENSDARG00000104280 bnip1b / BCL2 interacting protein 1b / BNIP1* / Q12981* / BCL2 interacting protein 1*  / reaction / complex
 ENSDARG00000045065 vti1a / vesicle transport through interaction with t-SNAREs 1A / O89116* / Q96AJ9*  / reaction / complex
 ENSDARG00000075030 stx10 / syntaxin 10 / O60499*  / reaction / complex
 ENSDARG00000078259 bnip1a / BCL2 interacting protein 1a / BNIP1* / Q6QD59* / Q12981* / BCL2 interacting protein 1* / Vesicle transport protein SEC20 *  / reaction / complex
 ENSDARG00000042742 stx6 / syntaxin 6 / O43752*  / complex / reaction
 ENSDARG00000100435 Q7SXP0 / sec22bb / SEC22 homolog B, vesicle trafficking protein b / SEC22B* / O08547* / O75396* / Vesicle-trafficking protein SEC22b * / SEC22 homolog B, vesicle trafficking protein (gene/p...  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr