ENSMUSG00000024983


Mus musculus

Features
Gene ID: ENSMUSG00000024983
  
Biological name :Vti1a
  
Synonyms : O89116 / vesicle transport through interaction with t-SNAREs 1A / Vti1a
  
Possible biological names infered from orthology : Q96AJ9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 55316295
Gene end: 55627309
  
Corresponding Affymetrix probe sets: 10464070 (MoGene1.0st)   1419189_at (Mouse Genome 430 2.0 Array)   1419190_at (Mouse Genome 430 2.0 Array)   1439876_at (Mouse Genome 430 2.0 Array)   1446365_at (Mouse Genome 430 2.0 Array)   1454077_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093644
Ensembl peptide - ENSMUSP00000153392
Ensembl peptide - ENSMUSP00000153629
NCBI entrez gene - 53611     See in Manteia.
MGI - MGI:1855699
RefSeq - XM_017318251
RefSeq - NM_001293685
RefSeq - NM_001293686
RefSeq - NM_016862
RefSeq - XM_006527188
RefSeq - XM_006527189
RefSeq - XM_006527190
RefSeq - XM_006527191
RefSeq - XM_006527192
RefSeq - XM_011247282
RefSeq - XM_006527184
RefSeq - XM_006527185
RefSeq Peptide - NP_001280614
RefSeq Peptide - NP_001280615
RefSeq Peptide - NP_058558
swissprot - O89116
swissprot - Q5FWJ7
swissprot - A0A286YDF2
Ensembl - ENSMUSG00000024983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vti1aENSDARG00000045065Danio rerio
 VTI1AENSGALG00000008880Gallus gallus
 VTI1AENSG00000151532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vti1b / vesicle transport through interaction with t-SNAREs 1B / Q9UEU0*ENSMUSG0000002112430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR007705  Vesicle transport v-SNARE, N-terminal
 IPR010989  SNARE
 IPR027027  GOSR2/Membrin/Bos1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006623 protein targeting to vacuole IBA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISS
 biological_processGO:0006891 intra-Golgi vesicle-mediated transport IBA
 biological_processGO:0006896 Golgi to vacuole transport IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0048280 vesicle fusion with Golgi apparatus ISS
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:0090161 Golgi ribbon formation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISS
 cellular_componentGO:0031201 SNARE complex ISS
 cellular_componentGO:0031902 late endosome membrane IBA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044306 neuron projection terminus ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity ISO


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0000960 abnormal sensory ganglia morphology "malformation or absence of a group of sensory neuron cell bodies" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004298 vestibular ganglion degeneration "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0006409 vestibular ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cell bodies, in the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008492 dorsal root ganglion degeneration "retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0020548 decreased optic chiasm size "decreased size of the optic chiasm" [MGI:smb]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / reaction / complex
 ENSMUSG00000026696 Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*  / complex
 ENSMUSG00000027522 Stx16 / Q8BVI5 / syntaxin 16 / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / complex
 ENSMUSG00000026470 Stx6 / Q9JKK1 / Syntaxin-6 / O43752*  / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / complex






 

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