ENSMUSG00000021124


Mus musculus

Features
Gene ID: ENSMUSG00000021124
  
Biological name :Vti1b
  
Synonyms : vesicle transport through interaction with t-SNAREs 1B / Vti1b
  
Possible biological names infered from orthology : Q9UEU0
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 79156017
Gene end: 79172667
  
Corresponding Affymetrix probe sets: 10401172 (MoGene1.0st)   1449003_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057462
Ensembl peptide - ENSMUSP00000124260
Ensembl peptide - ENSMUSP00000124464
Ensembl peptide - ENSMUSP00000124741
NCBI entrez gene - 53612     See in Manteia.
MGI - MGI:1855688
RefSeq - XM_011244143
RefSeq - NM_016800
RefSeq - XM_006516088
RefSeq Peptide - NP_058080
swissprot - E0CYE5
swissprot - Q91XH6
swissprot - F6UHS3
swissprot - F6T4B9
Ensembl - ENSMUSG00000021124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vti1bENSDARG00000039270Danio rerio
 VTI1BENSGALG00000009526Gallus gallus
 VTI1BENSG00000100568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vti1a / O89116 / vesicle transport through interaction with t-SNAREs 1A / Q96AJ9*ENSMUSG0000002498328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR007705  Vesicle transport v-SNARE, N-terminal
 IPR010989  SNARE


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0000960 abnormal sensory ganglia morphology "malformation or absence of a group of sensory neuron cell bodies" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003327 liver cysts "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0004298 vestibular ganglion degeneration "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0006409 vestibular ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cell bodies, in the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008492 dorsal root ganglion degeneration "retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0009342 enlarged gall bladder "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0020548 decreased optic chiasm size "decreased size of the optic chiasm" [MGI:smb]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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