ENSMUSG00000002395


Mus musculus

Features
Gene ID: ENSMUSG00000002395
  
Biological name :Use1
  
Synonyms : Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Use1
  
Possible biological names infered from orthology : Q9NZ43 / unconventional SNARE in the ER 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 71366848
Gene end: 71369732
  
Corresponding Affymetrix probe sets: 10572580 (MoGene1.0st)   1423817_s_at (Mouse Genome 430 2.0 Array)   1451130_at (Mouse Genome 430 2.0 Array)   1453430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105681
Ensembl peptide - ENSMUSP00000122406
Ensembl peptide - ENSMUSP00000019169
Ensembl peptide - ENSMUSP00000105680
NCBI entrez gene - 67023     See in Manteia.
MGI - MGI:1914273
RefSeq - NM_025917
RefSeq - XM_006509726
RefSeq - NM_001145780
RefSeq Peptide - NP_001139252
RefSeq Peptide - NP_080193
swissprot - D3Z6D3
swissprot - Q9CQ56
swissprot - E9Q496
Ensembl - ENSMUSG00000002395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 use1ENSDARG00000007250Danio rerio
 USE1ENSGALG00000003703Gallus gallus
 USE1ENSG00000053501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019150  Vesicle transport protein, Use1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007029 endoplasmic reticulum organization IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0060628 regulation of ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0071786 endoplasmic reticulum tubular network organization IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Use1tm1Aha/Use1tm1Aha
Genetic Background: Not Specified

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / complex
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / complex
 ENSMUSG00000020576 Nbas / neuroblastoma amplified sequence / A2RRP1*  / reaction
 ENSMUSG00000028999 Rint1 / Q8BZ36 / RAD50 interactor 1 / Q6NUQ1*  / reaction
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / reaction / complex
 ENSMUSG00000032264 Zw10 / O54692 / zw10 kinetochore protein / O43264*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex






 

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