ENSMUSG00000028999


Mus musculus

Features
Gene ID: ENSMUSG00000028999
  
Biological name :Rint1
  
Synonyms : Q8BZ36 / RAD50 interactor 1 / Rint1
  
Possible biological names infered from orthology : Q6NUQ1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 23787711
Gene end: 23820369
  
Corresponding Affymetrix probe sets: 10520080 (MoGene1.0st)   1431147_at (Mouse Genome 430 2.0 Array)   1456394_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112671
Ensembl peptide - ENSMUSP00000112763
Ensembl peptide - ENSMUSP00000030852
Ensembl peptide - ENSMUSP00000110766
NCBI entrez gene - 72772     See in Manteia.
MGI - MGI:1916233
RefSeq - NM_177323
RefSeq - XM_006535810
RefSeq - NM_001310467
RefSeq Peptide - NP_001297396
RefSeq Peptide - NP_796297
swissprot - D3YU07
swissprot - Q8BZ36
swissprot - D3YU54
Ensembl - ENSMUSG00000028999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rint1ENSDARG00000005547Danio rerio
 RINT1ENSGALG00000008123Gallus gallus
 RINT1ENSG00000135249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007528  RINT-1/Tip20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0048193 Golgi vesicle transport IEA
 biological_processGO:0060628 regulation of ER to Golgi vesicle-mediated transport ISO
 biological_processGO:1902504 regulation of signal transduction involved in mitotic G2 DNA damage checkpoint ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070939 Dsl1/NZR complex ISO


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0003570 uterine leiomyoma "a benign tumor derived from the smooth muscle tissue of the uterus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0010309 increased mesothelioma incidence "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0013488 increased keratoacanthoma incidence " greater than the expected number of low-grade skin tumors that originate in the pilosebaceous glands and closely resemble squamous cell carcinoma, occurring in a specific population in a given time period; keratoacanthomas are spontaneously regressing growths that rarely develop into invasive or metastatic carcinoma; in rare instances, multiple keratoacanthomas are associated with a disease process called Muir-Torre syndrome" [MGI:Anna]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0013751 increased cystadenoma incidence "greater than the expected number of a histologically benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed, occurring in a specific population in a given time period; in some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic" [http://medical-dictionary.thefreedictionary.com/cystoadenoma, MGI:Anna]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / reaction
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / reaction
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / reaction
 ENSMUSG00000032264 Zw10 / O54692 / zw10 kinetochore protein / O43264*  / complex
 ENSMUSG00000020576 Nbas / neuroblastoma amplified sequence / A2RRP1*  / complex






 

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