ENSMUSG00000027879


Mus musculus

Features
Gene ID: ENSMUSG00000027879
  
Biological name :Sec22b
  
Synonyms : O08547 / Sec22b / Vesicle-trafficking protein SEC22b
  
Possible biological names infered from orthology : O75396 / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 97901190
Gene end: 97923276
  
Corresponding Affymetrix probe sets: 10494583 (MoGene1.0st)   10343811 (MoGene1.0st)   1415766_at (Mouse Genome 430 2.0 Array)   1449063_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029476
Ensembl peptide - ENSMUSP00000142976
Ensembl peptide - ENSMUSP00000117579
Ensembl peptide - ENSMUSP00000113502
NCBI entrez gene - 20333     See in Manteia.
MGI - MGI:1338759
RefSeq - NM_011342
RefSeq Peptide - NP_035472
swissprot - D6RES2
swissprot - A0A0G2JF08
swissprot - E9Q6R3
swissprot - O08547
Ensembl - ENSMUSG00000027879
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SXP0ENSDARG00000100435Danio rerio
 sec22baENSDARG00000030108Danio rerio
 Q5ZJW4ENSGALG00000039704Gallus gallus
 O75396ENSG00000265808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BH47 / Sec22a / SEC22 homolog A, vesicle trafficking protein / Q96IW7*ENSMUSG0000003447333
Q8BXT9 / Sec22c / Vesicle-trafficking protein SEC22c / Q9BRL7* / SEC22 homolog C, vesicle trafficking protein*ENSMUSG0000006153625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR010908  Longin domain
 IPR011012  Longin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0048280 vesicle fusion with Golgi apparatus IBA
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / reaction / complex
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / reaction / complex
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / complex
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / complex / reaction
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / complex
 ENSMUSG00000020952 Scfd1 / Q8BRF7 / Sec1 family domain-containing protein 1 / Q8WVM8* / sec1 family domain containing 1*  / complex / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSMUSG00000026589 Q91XT4 / Sec16b / Protein transport protein Sec16B / Q96JE7* / SEC16 homolog B, endoplasmic reticulum export factor*  / complex / reaction
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / complex / reaction
 ENSMUSG00000024308 Tapbp / TAP binding protein / O15533*  / reaction
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / complex
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000037321 Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / complex
 ENSMUSG00000024339 Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / reaction / complex
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / reaction / complex
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / reaction / complex
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / reaction / complex
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / reaction / complex
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / reaction / complex
 ENSMUSG00000032757 Bet1 / O35623 / BET1 homolog / O15155* / Bet1 golgi vesicular membrane trafficking protein*  / reaction / complex
 ENSMUSG00000026924 Sec16a / SEC16 homolog A, endoplasmic reticulum export factor / O15027*  / reaction / complex
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction






 

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