ENSMUSG00000003814


Mus musculus

Features
Gene ID: ENSMUSG00000003814
  
Biological name :Calr
  
Synonyms : Calr / Calreticulin / P14211
  
Possible biological names infered from orthology : P27797
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84841850
Gene end: 84846934
  
Corresponding Affymetrix probe sets: 10580219 (MoGene1.0st)   1417606_a_at (Mouse Genome 430 2.0 Array)   1433806_x_at (Mouse Genome 430 2.0 Array)   1456170_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003912
NCBI entrez gene - 12317     See in Manteia.
MGI - MGI:88252
RefSeq - NM_007591
RefSeq Peptide - NP_031617
swissprot - B2MWM9
swissprot - P14211
Ensembl - ENSMUSG00000003814
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calrENSDARG00000076290Danio rerio
 CALRENSGALG00000040368Gallus gallus
 CALRENSG00000179218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calr4 / calreticulin 4ENSMUSG0000002855858
Calr3 / Q9D9Q6 / Calreticulin-3 / Q96L12*ENSMUSG0000001973245
Canx / P35564 / Calnexin / P27824*ENSMUSG0000002036841
Clgn / P52194 / Mus musculus calmegin (Clgn), transcript variant 2, mRNA. / O14967* / calmegin*ENSMUSG0000000219039


Protein motifs (from Interpro)
Interpro ID Name
 IPR001580  Calreticulin/calnexin
 IPR009033  Calreticulin/calnexin, P domain superfamily
 IPR009169  Calreticulin
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018124  Calreticulin/calnexin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002502 peptide antigen assembly with MHC class I protein complex IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway ISO
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0040020 regulation of meiotic nuclear division IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045665 negative regulation of neuron differentiation ISO
 biological_processGO:0045740 positive regulation of DNA replication ISO
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway ISO
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest ISO
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0090398 cellular senescence IMP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 biological_processGO:1901164 negative regulation of trophoblast cell migration ISO
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis ISO
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005788 endoplasmic reticulum lumen ISO
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0033018 sarcoplasmic reticulum lumen IEA
 cellular_componentGO:0042824 MHC class I peptide loading complex IMP
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IDA
 cellular_componentGO:0045335 phagocytic vesicle TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042562 hormone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding ISO
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Scavenging by Class A Receptors
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002952 ventricular cardiomyopathy "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010498 abnormal interventricular septum muscular part morphology "any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013283 failure of ventral body wall closure "failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality" [http://www.nbdpn.org/current/2008pdf/AMPresentations/EmbryologySadler.pdf, https://www.inkling.com/read/langmans-medical-embryology-thomas-sadler-12th/chapter-7/ch07-clinical-correlates-01, MGI:anna]
Show

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
Show

Allelic Composition: Calrtm1Mlk/Calrtm1Mlk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003402 O08795 / Prkcsh / protein kinase C substrate 80K-H / P14314*  / reaction
 ENSMUSG00000027248 Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*  / reaction / complex
 ENSMUSG00000038188 Q5ND28 / Scarf1 / Scavenger receptor class F member 1 / Q14162*  / reaction / complex
 ENSMUSG00000024308 Tapbp / TAP binding protein / O15533*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction
 ENSMUSG00000024339 Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000037321 Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / complex
 ENSMUSG00000071650 Ganab / Q8BHN3 / Neutral alpha-glucosidase AB / Q14697* / glucosidase II alpha subunit*  / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex






 

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