ENSMUSG00000003402


Mus musculus

Features
Gene ID: ENSMUSG00000003402
  
Biological name :Prkcsh
  
Synonyms : O08795 / Prkcsh / protein kinase C substrate 80K-H
  
Possible biological names infered from orthology : P14314
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 22002806
Gene end: 22014222
  
Corresponding Affymetrix probe sets: 10583788 (MoGene1.0st)   1416339_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003493
Ensembl peptide - ENSMUSP00000110987
Ensembl peptide - ENSMUSP00000149936
Ensembl peptide - ENSMUSP00000150233
NCBI entrez gene - 19089     See in Manteia.
MGI - MGI:107877
RefSeq - XM_006510096
RefSeq - NM_001293650
RefSeq - NM_001293651
RefSeq - NM_008925
RefSeq - XM_006510095
RefSeq Peptide - NP_001280580
RefSeq Peptide - NP_032951
RefSeq Peptide - NP_001280579
swissprot - O08795
swissprot - Q3U518
swissprot - A0A1L1ST83
Ensembl - ENSMUSG00000003402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcshENSDARG00000004470Danio rerio
 P14314ENSG00000130175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR026874  Glucosidase 2 subunit beta
 IPR028146  Glucosidase II beta subunit, N-terminal
 IPR036055  LDL receptor-like superfamily
 IPR036607  Glucosidase 2 subunit beta-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001889 liver development IGI
 biological_processGO:0006491 N-glycan processing IEA
 biological_processGO:0006807 nitrogen compound metabolic process IGI
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0072001 renal system development IGI
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051219 phosphoprotein binding ISO


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein phosphorylation
Calnexin/calreticulin cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

 MP:0003327 liver cysts "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Sec63tm1.1Som/Sec63tm1.1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Tg(Pdk1)248Som/0,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

Allelic Composition: Pkd2tm2Som/Pkd2+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

Allelic Composition: Pkd2tm2Som/Pkd2+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcshtm1Som/Prkcshtm1Som,Tg(Pdk1)248Som/0,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J

Allelic Composition: Pkd2tm2Som/Pkd2+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

 MP:0011344 abnormal loop of Henle ascending limb thick segment morphology "any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna]
Show

Allelic Composition: Cep290b2b1752Clo/Cep290b2b1752Clo
Genetic Background: C57BL/6J-Cep290b2b1752Clo

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Pkd1tm1Som/Pkd1+,Prkcshtm1Som/Prkcshtm1Som,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048578 Mlec / Q6ZQI3 / Malectin / Q14165*  / reaction
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000027248 Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*  / reaction
 ENSMUSG00000071650 Ganab / Q8BHN3 / Neutral alpha-glucosidase AB / Q14697* / glucosidase II alpha subunit*  / complex
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / reaction






 

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