ENSMUSG00000027248


Mus musculus

Features
Gene ID: ENSMUSG00000027248
  
Biological name :Pdia3
  
Synonyms : P27773 / Pdia3 / Protein disulfide-isomerase A3
  
Possible biological names infered from orthology : P30101 / protein disulfide isomerase family A member 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 121413775
Gene end: 121438687
  
Corresponding Affymetrix probe sets: 10475335 (MoGene1.0st)   1423423_at (Mouse Genome 430 2.0 Array)   1445330_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028683
Ensembl peptide - ENSMUSP00000119337
NCBI entrez gene - 14827     See in Manteia.
MGI - MGI:95834
RefSeq - NM_007952
RefSeq Peptide - NP_031978
swissprot - F6Q404
swissprot - P27773
Ensembl - ENSMUSG00000027248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdia3ENSDARG00000102640Danio rerio
 PDIA3ENSGALG00000008348Gallus gallus
 PDIA3ENSG00000167004Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdia4 / protein disulfide isomerase family A member 4 / P13667*ENSMUSG0000002582339
P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*ENSMUSG0000002513032
Pdia2 / D3Z6P0 / Protein disulfide-isomerase A2 / Q13087* / protein disulfide isomerase family A member 2*ENSMUSG0000002418429
Pdilt / Q9DAN1 / Protein disulfide-isomerase-like protein of the testis / Q8N807* / protein disulfide isomerase like, testis expressed*ENSMUSG0000003096821
Erp44 / Q9D1Q6 / Endoplasmic reticulum resident protein 44 / Q9BS26* / endoplasmic reticulum protein 44*ENSMUSG0000002834318
Tmx3 / Q8BXZ1 / Protein disulfide-isomerase TMX3 / Q96JJ7* / thioredoxin related transmembrane protein 3*ENSMUSG0000002461416
Erp27 / Q9D8U3 / Endoplasmic reticulum resident protein 27 / Q96DN0* / endoplasmic reticulum protein 27*ENSMUSG0000003021910


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IBA
 biological_processGO:0034976 response to endoplasmic reticulum stress IBA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003756 protein disulfide isomerase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pdia3tm1Gjh/Pdia3tm1Gjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003402 O08795 / Prkcsh / protein kinase C substrate 80K-H / P14314*  / reaction
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction / complex
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / complex / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex
 ENSMUSG00000071650 Ganab / Q8BHN3 / Neutral alpha-glucosidase AB / Q14697* / glucosidase II alpha subunit*  / reaction






 

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