ENSMUSG00000060802


Mus musculus

Features
Gene ID: ENSMUSG00000060802
  
Biological name :B2m
  
Synonyms : B2m / Beta-2-microglobulin / P01887
  
Possible biological names infered from orthology : P61769
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 122147686
Gene end: 122153083
  
Corresponding Affymetrix probe sets: 10475414 (MoGene1.0st)   1427511_at (Mouse Genome 430 2.0 Array)   1449289_a_at (Mouse Genome 430 2.0 Array)   1452428_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099534
NCBI entrez gene - 12010     See in Manteia.
MGI - MGI:88127
RefSeq - NM_009735
RefSeq Peptide - NP_033865
swissprot - P01887
Ensembl - ENSMUSG00000060802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b2mENSDARG00000053136Danio rerio
 b2mlENSDARG00000015887Danio rerio
 zmp:0000001138ENSDARG00000071168Danio rerio
 B2MENSGALG00000002160Gallus gallus
 B2MENSG00000166710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015707  Beta-2-Microglobulin
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IMP
 biological_processGO:0002237 response to molecule of bacterial origin IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA
 biological_processGO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0006826 iron ion transport IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0010977 negative regulation of neuron projection development IGI
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0033216 ferric iron import IMP
 biological_processGO:0042026 protein refolding IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:0071283 cellular response to iron(III) ion IMP
 biological_processGO:1900121 negative regulation of receptor binding IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 biological_processGO:1900390 regulation of iron ion import IEA
 biological_processGO:1904434 positive regulation of ferrous iron binding IEA
 biological_processGO:1904437 positive regulation of transferrin receptor binding IEA
 biological_processGO:1904440 positive regulation of ferrous iron import across plasma membrane ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:1990712 HFE-transferrin receptor complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 signaling
Neutrophil degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae
Genetic Background: involves: 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: NOD.129P2-B2mtm1Unc

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(GFAP-B2m)9Mdos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(GFAP-B2m)#Mdos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae
Genetic Background: involves: 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: B2mtm1Unc/B2m+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(KRT14-HPV16E7)2304Plam/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: B2mtm1Unc/B2mtm1Unc,X/Yaa
Genetic Background: BXSB.129P2(B6)-B2mtm1Unc/Dcr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm3.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,X/Yaa
Genetic Background: BXSB.129P2(B6)-B2mtm1Unc/Dcr

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,X/Yaa
Genetic Background: BXSB.129P2(B6)-B2mtm1Unc/Dcr

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(B2M)55Hpl/Tg(B2M)55Hpl,Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(TcraAI4)1Dvs/0,Tg(TcrbAI4)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: NOD.129P2-B2mtm1Unc

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(GFAP-B2m)9Mdos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(GFAP-B2m)#Mdos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(B2M)55Hpl/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(TcraAI4)1Dvs/0,Tg(TcrbAI4)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: NOD.129P2-B2mtm1Unc

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0005638 hemochromatosis "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:64456]
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Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae
Genetic Background: involves: 129S2/SvPas

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vsx2or-J/Vsx2or-J,Modor3CASA/Rk/?
Genetic Background: involves: 129S1/Sv * CASA/Rk

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: either: B6.129S2-Cd4tm1Jrp or B10.Cg-Cd4tm1Jrp

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tg(LckNotch1)9Erob/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic Background: involves: 129P2/OlaHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: B2mtm1Jae/B2mtm1Jae
Genetic Background: involves: 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-D1tm1Bpe/H2-D1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

Allelic Composition: B2mtm1Unc/B2m+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tg(LckNotch1)9Erob/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008350 increased gamma-delta intraepithelial T cell number "greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2tm1Hor/Il2tm1Hor
Genetic Background: involves: 129 * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0008696 increased interleukin-3 secretion "increase in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc
Genetic Background: B6.129P2-B2mtm1Unc/J

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tbptm1.1Ees/Tbptm1.1Ees
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / complex / reaction
 ENSMUSG00000002015 Bcap31 / Q61335 / B-cell receptor-associated protein 31 / P51572*  / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / complex / reaction
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSMUSG00000030165 Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*  / complex
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000027248 Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*  / reaction / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / reaction / complex
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / complex / reaction
 ENSMUSG00000028076 Cd1d1 / CD1D* / P15813* / CD1d molecule*  / complex
 ENSMUSG00000023845 Lnpep / Q8C129 / Leucyl-cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*  / complex
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / complex / reaction
 ENSMUSG00000057439 Kir3dl2 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR2DL1* / KIR3DL3* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL1* / killer cell immunoglobulin like receptor, two Ig domains and lo...  / complex / reaction
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000053044 Cd8b1 / P10300 / T-cell surface glycoprotein CD8 beta chain / CD8B* / CD8B2* / P10966* / CD8b molecule* / CD8b2 molecule*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000053977 Cd8a / P01731 / T-cell surface glycoprotein CD8 alpha chain / P01732* / CD8a molecule*  / complex / reaction
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000031424 Kir3dl1 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR3DL2* / KIR2DL1* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL3* / killer cell immunoglobulin like receptor, two Ig domains and lo...  / complex / reaction






 

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