ENSMUSG00000053044


Mus musculus

Features
Gene ID: ENSMUSG00000053044
  
Biological name :Cd8b1
  
Synonyms : Cd8b1 / P10300 / T-cell surface glycoprotein CD8 beta chain
  
Possible biological names infered from orthology : CD8B / CD8B2 / CD8b2 molecule / CD8b molecule / P10966
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 71322788
Gene end: 71337494
  
Corresponding Affymetrix probe sets: 10538979 (MoGene1.0st)   1426170_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070131
NCBI entrez gene - 12526     See in Manteia.
MGI - MGI:88347
RefSeq - NM_009858
RefSeq Peptide - NP_033988
swissprot - P10300
swissprot - Q3TEK8
Ensembl - ENSMUSG00000053044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD8BENSGALG00000015902Gallus gallus
 CD8BENSG00000172116Homo sapiens
 CD8B2ENSG00000254126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8b1tm1Litt/Cd8b1+,Tg(Cd8b1)46Erob/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Cd8b1M1Btlr/Cd8b1M1Btlr
Genetic Background: C57BL/6J-Cd8b1M1Btlr

Allelic Composition: Cd8b1M1Btlr/Cd8b1+
Genetic Background: C57BL/6J-Cd8b1M1Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0008349 abnormal gamma-delta intraepithelial T cell morphology "any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Cd8b1tm1Litt/Cd8b1tm1Litt,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Cd8b1M1Btlr/Cd8b1M1Btlr
Genetic Background: C57BL/6J-Cd8b1M1Btlr

Allelic Composition: Cd8b1M1Btlr/Cd8b1+
Genetic Background: C57BL/6J-Cd8b1M1Btlr

 MP:0020155 enhanced humoral immune response "enhanced response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Cd8b1M1Btlr/Cd8b1M1Btlr
Genetic Background: C57BL/6J-Cd8b1M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex
 ENSMUSG00000053977 Cd8a / P01731 / T-cell surface glycoprotein CD8 alpha chain / P01732* / CD8a molecule*  / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex / reaction






 

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