MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
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Allelic Composition: Pkhd1tm1Som/Pkhd1tm1Som Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Pkhd1tm1Som/Pkhd1tm1Som Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0000727 | absent CD4-8+ cells | "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Lattm1Mal/Lattm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm
Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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MP:0001825 | arrested T cell development | "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Cd3etm1Lov/Cd3etm1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov Genetic Background: Not Specified
Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Lattm1Mal/Lattm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cd3em1Btlr/Cd3em1Btlr Genetic Background: C57BL/6J-Cd3em1Btlr
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MP:0002026 | leukemia | "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+ Genetic Background: involves: 129S4/SvJae
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pkhd1tm1Som/Pkhd1tm1Som Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0002145 | abnormal T lymphocyte development | "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tbx5tm1.2Jse/Tbx5tm1.2Jse Genetic Background: Not Specified
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
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MP:0002407 | abnormal double-negative T cell | "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Lattm4Mal/Lattm4Mal,Trdctm1Mal/Trdctm1Mal Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
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MP:0002408 | abnormal double-positive T cell | "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tbx5tm1.2Jse/Tbx5tm1.2Jse Genetic Background: Not Specified
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MP:0003790 | absent CD4+8- cells | "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Lattm1Mal/Lattm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0004816 | abnormal class switch recombination | "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3ap1m1Btlr/Pik3ap1m1Btlr Genetic Background: involves: C57BL/6J
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MP:0004918 | abnormal negative T cell selection | "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383] |
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
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MP:0004919 | abnormal positive T cell selection | "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368] |
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
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MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
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MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1 Genetic Background: involves: C57BL/6
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
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MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cd3etm1Lov/Cd3etm1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov Genetic Background: Not Specified
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cd3etm1Lov/Cd3etm1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov Genetic Background: Not Specified
Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
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MP:0006387 | abnormal T cell number | "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tbx5tm1.2Jse/Tbx5tm1.2Jse Genetic Background: Not Specified
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MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3em1Btlr/Cd3em1Btlr Genetic Background: C57BL/6J-Cd3em1Btlr
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MP:0008037 | abnormal T cell morphology | "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Lov/Cd3etm1Lov Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov Genetic Background: Not Specified
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MP:0008070 | absent T cells | "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
Allelic Composition: Cd3em1Btlr/Cd3em1Btlr Genetic Background: C57BL/6J-Cd3em1Btlr
Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008076 | abnormal CD4-positive T cell differentiation | "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0008827 | abnormal thymus cell ratio | "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal Genetic Background: C57BL/6-Cd3etm1Mal
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MP:0009787 | increased susceptibility to infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1 Genetic Background: involves: C57BL/6
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MP:0010133 | increased DN3 thymocyte number | "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807] |
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Allelic Composition: Tbx5tm1.2Jse/Tbx5tm1.2Jse Genetic Background: Not Specified
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraTcrb)1100Mjb/0 Genetic Background: involves: C57BL/6
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J
Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0010336 | increased acute lymphoblastic leukemia incidence | |
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+ Genetic Background: involves: 129S4/SvJae
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