ENSMUSG00000023274


Mus musculus

Features
Gene ID: ENSMUSG00000023274
  
Biological name :Cd4
  
Synonyms : Cd4 / P06332 / T-cell surface glycoprotein CD4
  
Possible biological names infered from orthology : CD4 molecule / P01730
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124864692
Gene end: 124888221
  
Corresponding Affymetrix probe sets: 10547894 (MoGene1.0st)   1419696_at (Mouse Genome 430 2.0 Array)   1427779_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024044
NCBI entrez gene - 12504     See in Manteia.
MGI - MGI:88335
RefSeq - XM_006505462
RefSeq - NM_013488
RefSeq - XM_006505461
RefSeq Peptide - NP_038516
swissprot - Q3TSV7
swissprot - P06332
Ensembl - ENSMUSG00000023274
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD4ENSGALG00000014477Gallus gallus
 CD4ENSG00000010610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000973  T-cell surface antigen CD4
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008424  Immunoglobulin C2-set
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015274  CD4, extracellular
 IPR021963  T cell CD4 receptor C-terminal region
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006948 induction by virus of host cell-cell fusion IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0032507 maintenance of protein location in cell ISO
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0035397 helper T cell enhancement of adaptive immune response IMP
 biological_processGO:0035723 interleukin-15-mediated signaling pathway IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045058 T cell selection ISS
 biological_processGO:0045657 positive regulation of monocyte differentiation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0050863 regulation of T cell activation IEA
 biological_processGO:0050870 positive regulation of T cell activation IDA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042011 interleukin-16 binding IEA
 molecular_functionGO:0042012 interleukin-16 receptor activity IEA
 molecular_functionGO:0042289 MHC class II protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Asy/a
Genetic Background: C57BL/6J-Asy/a/J

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: PL.129S2(B6)-Cd4tm1Mak/Rdgz

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: SJL.129S2(B6)-Cd4tm1Mak/Rdgz

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: SJL.129S2(B6)-Cd4tm1Mak/Rdgz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm4.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm4.1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cd4tm2Litt/Cd4tm2Litt,Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cd4tm1.1Tich/Cd4tm1.1Tich,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002347 abnormal lymph node T cell domain "anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cd4sesh/Cd4sesh
Genetic Background: C57BL/6JAnu-Cd4sesh/Apb

Allelic Composition: Cd4maat/Cd4maat
Genetic Background: C57BL/6JAnu-Cd4maat/Apb

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asy/a
Genetic Background: C57BL/6J-Asy/a/J

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: PL.129S2(B6)-Cd4tm1Mak/Rdgz

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: SJL.129S2(B6)-Cd4tm1Mak/Rdgz

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cd4sesh/Cd4sesh
Genetic Background: C57BL/6JAnu-Cd4sesh/Apb

Allelic Composition: Cd4maat/Cd4maat
Genetic Background: C57BL/6JAnu-Cd4maat/Apb

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: Cd4del/Cd4del
Genetic Background: C57BR/cdJ-Cd4del

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Cd4del/Cd4del
Genetic Background: C57BR/cdJ-Cd4del

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd4thth/Cd4thth
Genetic Background: C57BL/6JSfdAnu-Cd4thth

Allelic Composition: Cd4m1Btlr/Cd4m1Btlr
Genetic Background: C57BL/6J-Cd4m1Btlr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm4.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm4.1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,SordC57BL/Lia/SordC57BL/Lia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(TcraAI4)1Dvs/0,Tg(TcrbAI4)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Nik/Cd4tm1Nik,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

Allelic Composition: Cd4tm2Litt/Cd4tm2Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4sesh/Cd4sesh
Genetic Background: C57BL/6JAnu-Cd4sesh/Apb

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Tani/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Yzo/Cd4tm1Yzo,Tg(Cd8a-cre,GFP)1Yzo/?
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cd4tm1.1Tich/Cd4tm1.1Tich,Tg(ACTB-tTS)1Mllo/?
Genetic Background: involves: 129 * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-icre)3779Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt
Genetic Background: involves: 129S2/SvPas

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-icre)3779Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-icre)3779Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Doi/Cd4tm1Doi,Lag3tm1Doi/Lag3tm1Doi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt
Genetic Background: involves: 129S2/SvPas

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1(cre/ERT2)Thbu/Cd4+,Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Knw/Cd4tm1Knw
Genetic Background: B6.129S-Cd4tm1Knw/J

Allelic Composition: Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: either: B6.129S2-Cd4tm1Jrp or B10.Cg-Cd4tm1Jrp

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm4.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm4.1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cd4maat/Cd4maat
Genetic Background: C57BL/6JAnu-Cd4maat/Apb

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm1Knw/Cd4tm1Knw
Genetic Background: B6.129S-Cd4tm1Knw/J

Allelic Composition: Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: either: B6.129S2-Cd4tm1Jrp or B10.Cg-Cd4tm1Jrp

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm1Jrp/Cd4tm1Jrp
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd4del/Cd4del
Genetic Background: C57BR/cdJ-Cd4del

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm4.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm4.1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Cd4maat/Cd4maat
Genetic Background: C57BL/6JAnu-Cd4maat/Apb

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008345 abnormal gamma-delta T cell number "anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0008698 abnormal interleukin-4 secretion "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Litt,Foxp3sf Otcspf/Y
Genetic Background: involves: 129/Rl * 129S2/SvPas

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Cd8atm1Mak/Cd8atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Cd4m1Btlr/Cd4m1Btlr
Genetic Background: C57BL/6J-Cd4m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001741 Il16 / O54824 / Pro-interleukin-16 Interleukin-16 / Q14005* / interleukin 16*  / reaction / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr