ENSMUSG00000027843


Mus musculus

Features
Gene ID: ENSMUSG00000027843
  
Biological name :Ptpn22
  
Synonyms : P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22
  
Possible biological names infered from orthology : protein tyrosine phosphatase, non-receptor type 22 / Q9Y2R2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 103859795
Gene end: 103912247
  
Corresponding Affymetrix probe sets: 10494978 (MoGene1.0st)   1417995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029433
Ensembl peptide - ENSMUSP00000122307
NCBI entrez gene - 19260     See in Manteia.
MGI - MGI:107170
RefSeq - XM_017319504
RefSeq - NM_008979
RefSeq - XM_006501150
RefSeq - XM_011240041
RefSeq - XM_011240042
RefSeq - XM_006501148
RefSeq - XM_006501149
RefSeq Peptide - NP_033005
swissprot - P29352
swissprot - E9QAS3
Ensembl - ENSMUSG00000027843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn22ENSDARG00000104197Danio rerio
 PTPN22ENSGALG00000021656Gallus gallus
 PTPN22ENSG00000134242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG0000002877134
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG0000002612621
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG0000002453913
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG0000002754013
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022313
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542913
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531413
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG0000003229012
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591612
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015412
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016276  Non-receptor tyrosine-protein phosphatase 22
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002685 regulation of leukocyte migration IMP
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0010507 negative regulation of autophagy ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032481 positive regulation of type I interferon production ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032817 regulation of natural killer cell proliferation ISO
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0034157 positive regulation of toll-like receptor 7 signaling pathway IMP
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IMP
 biological_processGO:0035644 phosphoanandamide dephosphorylation IDA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IMP
 biological_processGO:0043508 negative regulation of JUN kinase activity ISO
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0050856 regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway ISS
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0071225 cellular response to muramyl dipeptide IDA
 biological_processGO:0071663 positive regulation of granzyme B production IMP
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IMP
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1902523 positive regulation of protein K63-linked ubiquitination IMP
 biological_processGO:1902715 positive regulation of interferon-gamma secretion ISO
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IMP
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IMP
 biological_processGO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISO
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gusbmps/Gusbmps,KitW-41J/KitW-41J
Genetic Background: B6(C)-KitW-41J Gusbmps/BrkJ

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002869 increased insulin autoantibody level "elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0008191 abnormal follicular B cell physiology "abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Genetic Background: involves: C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22+
Genetic Background: involves: 129 * C57BL/6

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction






 

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