ENSMUSG00000030223


Mus musculus

Features
Gene ID: ENSMUSG00000030223
  
Biological name :Ptpro
  
Synonyms : E9Q612 / Ptpro / Receptor-type tyrosine-protein phosphatase O
  
Possible biological names infered from orthology : protein tyrosine phosphatase, receptor type O / Q16827
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 137252319
Gene end: 137463233
  
Corresponding Affymetrix probe sets: 10542414 (MoGene1.0st)   1417676_a_at (Mouse Genome 430 2.0 Array)   1425863_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076364
Ensembl peptide - ENSMUSP00000144870
Ensembl peptide - ENSMUSP00000131764
Ensembl peptide - ENSMUSP00000127112
NCBI entrez gene - 19277     See in Manteia.
MGI - MGI:1097152
RefSeq - NM_001164401
RefSeq - NM_011216
RefSeq - NM_001164403
RefSeq - NM_001164402
RefSeq Peptide - NP_035346
RefSeq Peptide - NP_001157873
RefSeq Peptide - NP_001157874
RefSeq Peptide - NP_001157875
swissprot - E9Q612
swissprot - A0A0N4SUY2
swissprot - E9PVJ6
swissprot - E9Q4I1
Ensembl - ENSMUSG00000030223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptproENSDARG00000110470Danio rerio
 PTPROENSGALG00000013085Gallus gallus
 PTPROENSG00000151490Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015427
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591621
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531418
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542918
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194010
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG0000003229010
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG000000261268
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG000000245398
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG000000287718
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG000000275408
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG000000278438


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0003093 regulation of glomerular filtration IMP
 biological_processGO:0003105 negative regulation of glomerular filtration IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0036060 slit diaphragm assembly IMP
 biological_processGO:0072112 glomerular visceral epithelial cell differentiation IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0043197 dendritic spine IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Acvrl1tm1Dgen/Acvrl1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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