ENSMUSG00000032290


Mus musculus

Features
Gene ID: ENSMUSG00000032290
  
Biological name :Ptpn9
  
Synonyms : O35239 / protein tyrosine phosphatase, non-receptor type 9 / Ptpn9
  
Possible biological names infered from orthology : P43378
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 56994923
Gene end: 57062807
  
Corresponding Affymetrix probe sets: 10585610 (MoGene1.0st)   1451037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150426
Ensembl peptide - ENSMUSP00000034832
NCBI entrez gene - 56294     See in Manteia.
MGI - MGI:1928376
RefSeq - NM_019651
RefSeq Peptide - NP_062625
swissprot - A0A1L1STP0
swissprot - O35239
swissprot - Q2M4G8
Ensembl - ENSMUSG00000032290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn9aENSDARG00000077495Danio rerio
 PTPN9ENSGALG00000001664Gallus gallus
 PTPN9ENSG00000169410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015426
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531425
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542925
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591622
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022321
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG0000002453918
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG0000002754018
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG0000002612618
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG0000002877117
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194017
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG0000002784316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036273  CRAL/TRIO, N-terminal domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0044306 neuron projection terminus ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000440 domed skull 
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009929 meningomyelocele "hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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