ENSMUSG00000026126


Mus musculus

Features
Gene ID: ENSMUSG00000026126
  
Biological name :Ptpn18
  
Synonyms : protein tyrosine phosphatase, non-receptor type 18 / Ptpn18 / Q61152
  
Possible biological names infered from orthology : Q99952
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 34459762
Gene end: 34475733
  
Corresponding Affymetrix probe sets: 10345370 (MoGene1.0st)   1419125_at (Mouse Genome 430 2.0 Array)   1444894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027302
Ensembl peptide - ENSMUSP00000139885
Ensembl peptide - ENSMUSP00000140436
NCBI entrez gene - 19253     See in Manteia.
MGI - MGI:108410
RefSeq - XM_017319374
RefSeq - NM_011206
RefSeq - XM_006495800
RefSeq Peptide - NP_035336
swissprot - Q3V441
swissprot - Q61152
swissprot - A0A087WPR5
Ensembl - ENSMUSG00000026126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn18ENSDARG00000006308Danio rerio
 PTPN18ENSG00000072135Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG0000002877137
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG0000002784337
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531425
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542925
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG0000003229024
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194023
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015423
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG0000002754023
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591621
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG0000002453921
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction






 

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