ENSG00000072135


Homo sapiens

Features
Gene ID: ENSG00000072135
  
Biological name :PTPN18
  
Synonyms : protein tyrosine phosphatase, non-receptor type 18 / PTPN18 / Q99952
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q21.1
Gene start: 130356007
Gene end: 130375409
  
Corresponding Affymetrix probe sets: 1569552_at (Human Genome U133 Plus 2.0 Array)   203555_at (Human Genome U133 Plus 2.0 Array)   213521_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411750
Ensembl peptide - ENSP00000175756
Ensembl peptide - ENSP00000310092
Ensembl peptide - ENSP00000387031
NCBI entrez gene - 26469     See in Manteia.
OMIM - 606587
RefSeq - XM_017003798
RefSeq - NM_001142370
RefSeq - NM_014369
RefSeq - XM_006712416
RefSeq - XM_006712417
RefSeq Peptide - NP_055184
RefSeq Peptide - NP_001135842
swissprot - F8WBM9
swissprot - Q99952
swissprot - E7EMB8
Ensembl - ENSG00000072135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn18ENSDARG00000006308Danio rerio
 Ptpn18ENSMUSG00000026126Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12ENSG0000012794738
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG0000013424237
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003125
PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type JENSG0000014917724
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG0000020417923
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG0000016941023
PTPRB / P23467 / protein tyrosine phosphatase, receptor type BENSG0000012732923
PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1ENSG0000019639622
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930421
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149020
PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2ENSG0000017535420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex






 

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