ENSG00000175354


Homo sapiens

Features
Gene ID: ENSG00000175354
  
Biological name :PTPN2
  
Synonyms : P17706 / protein tyrosine phosphatase, non-receptor type 2 / PTPN2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: p11.21
Gene start: 12785478
Gene end: 12929643
  
Corresponding Affymetrix probe sets: 204935_at (Human Genome U133 Plus 2.0 Array)   213136_at (Human Genome U133 Plus 2.0 Array)   213137_s_at (Human Genome U133 Plus 2.0 Array)   241622_at (Human Genome U133 Plus 2.0 Array)   241623_at (Human Genome U133 Plus 2.0 Array)   241983_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000493693
Ensembl peptide - ENSP00000468408
Ensembl peptide - ENSP00000494336
Ensembl peptide - ENSP00000496181
Ensembl peptide - ENSP00000311857
Ensembl peptide - ENSP00000320298
Ensembl peptide - ENSP00000320546
Ensembl peptide - ENSP00000464719
Ensembl peptide - ENSP00000464937
Ensembl peptide - ENSP00000466206
Ensembl peptide - ENSP00000466936
Ensembl peptide - ENSP00000467043
Ensembl peptide - ENSP00000467823
Ensembl peptide - ENSP00000468012
Ensembl peptide - ENSP00000468155
NCBI entrez gene - 5771     See in Manteia.
OMIM - 176887
RefSeq - XM_017025888
RefSeq - NM_001207013
RefSeq - NM_001308287
RefSeq - NM_002828
RefSeq - NM_080422
RefSeq - NM_080423
RefSeq - XM_005258124
RefSeq - XM_005258125
RefSeq - XM_011525705
RefSeq - XM_011525706
RefSeq - XM_017025884
RefSeq - XM_017025885
RefSeq - XM_017025886
RefSeq - XM_017025887
RefSeq Peptide - NP_002819
RefSeq Peptide - NP_536347
RefSeq Peptide - NP_536348
RefSeq Peptide - NP_001295216
RefSeq Peptide - NP_001193942
swissprot - K7ENP9
swissprot - K7EQG9
swissprot - K7ER87
swissprot - K7ERU1
swissprot - P17706
swissprot - A8K3N4
swissprot - D3DUJ3
swissprot - K7EIE9
swissprot - K7EIY0
swissprot - K7ELS9
Ensembl - ENSG00000175354
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn2aENSDARG00000016481Danio rerio
 ptpn2bENSDARG00000035986Danio rerio
 PTPN2ENSGALG00000013867Gallus gallus
 Ptpn2ENSMUSG00000024539Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1ENSG0000019639656
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG0000016941026
PTPRB / P23467 / protein tyrosine phosphatase, receptor type BENSG0000012732926
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG0000013424226
PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12ENSG0000012794724
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149024
PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type JENSG0000014917723
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003123
PTPN18 / Q99952 / protein tyrosine phosphatase, non-receptor type 18ENSG0000007213523
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930422
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG0000020417921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0045650 negative regulation of macrophage differentiation IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050922 negative regulation of chemotaxis IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070104 negative regulation of interleukin-6-mediated signaling pathway IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IMP
 biological_processGO:1902206 negative regulation of interleukin-2-mediated signaling pathway IMP
 biological_processGO:1902215 negative regulation of interleukin-4-mediated signaling pathway IEA
 biological_processGO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway IEA
 biological_processGO:1902233 negative regulation of positive thymic T cell selection IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019905 syntaxin binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0097677 STAT family protein binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of MET activity
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000689 Dental malocclusion "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." [HPO:curators]
Show

 HP:0001094 Iridocyclitis 
Show

 HP:0001373 Joint dislocation "Displacement or malalignment of joints." [HPO:curators]
Show

 HP:0001376 Decreased mobility of joints 
Show

 HP:0001386 Joint swelling 
Show

 HP:0002186 Apraxia "A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." [HPO:curators]
Show

 HP:0002829 Arthralgia 
Show

 HP:0003493 Antinuclear antibody positive 
Show

 HP:0003565 Elevated erythrocyte sedimentation rate 
Show

 HP:0005681 Rheumatoid arthritis, juvenile 
Show

 HP:0005764 Polyarticular arthritis 
Show

 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr