ENSMUSG00000024539


Mus musculus

Features
Gene ID: ENSMUSG00000024539
  
Biological name :Ptpn2
  
Synonyms : Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2
  
Possible biological names infered from orthology : P17706 / protein tyrosine phosphatase, non-receptor type 2
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 67665511
Gene end: 67724595
  
Corresponding Affymetrix probe sets: 10459590 (MoGene1.0st)   1417140_a_at (Mouse Genome 430 2.0 Array)   1425197_at (Mouse Genome 430 2.0 Array)   1425198_at (Mouse Genome 430 2.0 Array)   1438562_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025420
Ensembl peptide - ENSMUSP00000112675
Ensembl peptide - ENSMUSP00000113182
NCBI entrez gene - 19255     See in Manteia.
MGI - MGI:97806
RefSeq - XM_011246859
RefSeq - NM_001127177
RefSeq - NM_008977
RefSeq - XM_006525723
RefSeq - XM_011246858
RefSeq Peptide - NP_001120649
RefSeq Peptide - NP_033003
swissprot - Q06180
swissprot - D3Z6W2
Ensembl - ENSMUSG00000024539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn2aENSDARG00000016481Danio rerio
 ptpn2bENSDARG00000035986Danio rerio
 PTPN2ENSGALG00000013867Gallus gallus
 PTPN2ENSG00000175354Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG0000002754055
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542927
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG0000003229027
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015426
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG0000002784326
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022325
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG0000002612624
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG0000002877124
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531424
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194023
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IPI
 biological_processGO:0006470 protein dephosphorylation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0010888 negative regulation of lipid storage IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045650 negative regulation of macrophage differentiation IMP
 biological_processGO:0045722 positive regulation of gluconeogenesis IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0050922 negative regulation of chemotaxis IMP
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IMP
 biological_processGO:0070104 negative regulation of interleukin-6-mediated signaling pathway IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:1902206 negative regulation of interleukin-2-mediated signaling pathway IMP
 biological_processGO:1902215 negative regulation of interleukin-4-mediated signaling pathway IMP
 biological_processGO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway IMP
 biological_processGO:1902233 negative regulation of positive thymic T cell selection IMP
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response IMP
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0097677 STAT family protein binding IPI


Pathways (from Reactome)
Pathway description
Negative regulation of MET activity
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: TfrcMvd001/Tfrc+
Genetic Background: C3HeB/FeJ-TfrcMvd001

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Kry/Ptpn2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: B6.129S4(C)-Ptpn2tm1Mtr

Allelic Composition: Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
Genetic Background: B6.Cg-Ptpn2tm2.1Ttig

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

 MP:0011722 abnormal ossification involved in bone maturation "anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the developing skeleton from its formation to its mature state" [GO:0043931]
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Allelic Composition: Ptpn2tm1Mtr/Ptpn2tm1Mtr
Genetic Background: C.129S4-Ptpn2tm1Mtr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction






 

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