ENSMUSG00000020154


Mus musculus

Features
Gene ID: ENSMUSG00000020154
  
Biological name :Ptprb
  
Synonyms : B2RU80 / protein tyrosine phosphatase, receptor type, B / Ptprb
  
Possible biological names infered from orthology : P23467
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 116275523
Gene end: 116389535
  
Corresponding Affymetrix probe sets: 10366476 (MoGene1.0st)   1427486_at (Mouse Genome 430 2.0 Array)   1436367_at (Mouse Genome 430 2.0 Array)   1453908_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089805
Ensembl peptide - ENSMUSP00000151821
NCBI entrez gene - 19263     See in Manteia.
MGI - MGI:97809
RefSeq - NM_029928
RefSeq - XM_006513378
RefSeq Peptide - NP_084204
swissprot - B2RU80
swissprot - A0A1W2P7W3
Ensembl - ENSMUSG00000020154
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprbENSDARG00000076624Danio rerio
 PTPRBENSGALG00000010049Gallus gallus
 PTPRBENSG00000127329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591621
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531417
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022317
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542912
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG000000322908
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG000000219406
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG000000287715
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG000000245395
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG000000261265
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG000000278435
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG000000275405


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000772  Ricin B, lectin domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR035992  Ricin B-like lectins
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000263 absent organized vascular network "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: B6.129S6-Hcrttm1Ywa

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: B6.129S6-Hcrttm1Ywa

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0012254 absent intersomitic vessels "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Plxnb2m597804Hubr/Plxnb2m597804Hubr
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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