ENSG00000127329


Homo sapiens

Features
Gene ID: ENSG00000127329
  
Biological name :PTPRB
  
Synonyms : P23467 / protein tyrosine phosphatase, receptor type B / PTPRB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q15
Gene start: 70515866
Gene end: 70637440
  
Corresponding Affymetrix probe sets: 1560105_at (Human Genome U133 Plus 2.0 Array)   205846_at (Human Genome U133 Plus 2.0 Array)   217177_s_at (Human Genome U133 Plus 2.0 Array)   230250_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448349
Ensembl peptide - ENSP00000447302
Ensembl peptide - ENSP00000448058
Ensembl peptide - ENSP00000261266
Ensembl peptide - ENSP00000334928
Ensembl peptide - ENSP00000438927
Ensembl peptide - ENSP00000446934
Ensembl peptide - ENSP00000446982
NCBI entrez gene - 5787     See in Manteia.
OMIM - 176882
RefSeq - XM_017019724
RefSeq - NM_001109754
RefSeq - NM_001206971
RefSeq - NM_001206972
RefSeq - NM_002837
RefSeq - XM_006719528
RefSeq - XM_006719529
RefSeq - XM_011538614
RefSeq - XM_017019723
RefSeq Peptide - NP_001193901
RefSeq Peptide - NP_001317133
RefSeq Peptide - NP_002828
RefSeq Peptide - NP_001103224
RefSeq Peptide - NP_001193900
swissprot - P23467
swissprot - Q6ZR19
swissprot - F8VU56
swissprot - H0YHE8
swissprot - F8VSD5
Ensembl - ENSG00000127329
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprbENSDARG00000076624Danio rerio
 PTPRBENSGALG00000010049Gallus gallus
 PtprbENSMUSG00000020154Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930419
PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type JENSG0000014917716
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149016
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003113
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG000001694107
PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2ENSG000001753545
PTPN18 / Q99952 / protein tyrosine phosphatase, non-receptor type 18ENSG000000721355
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG000002041795
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG000001342425
PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1ENSG000001963965
PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12ENSG000001279474


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000772  Ricin B, lectin domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR035992  Ricin B-like lectins
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0006796 phosphate-containing compound metabolic process TAS
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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