ENSG00000196396


Homo sapiens

Features
Gene ID: ENSG00000196396
  
Biological name :PTPN1
  
Synonyms : P18031 / protein tyrosine phosphatase, non-receptor type 1 / PTPN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.13
Gene start: 50510321
Gene end: 50585241
  
Corresponding Affymetrix probe sets: 202716_at (Human Genome U133 Plus 2.0 Array)   217686_at (Human Genome U133 Plus 2.0 Array)   217689_at (Human Genome U133 Plus 2.0 Array)   239526_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360683
Ensembl peptide - ENSP00000437732
NCBI entrez gene - 5770     See in Manteia.
OMIM - 176885
RefSeq - NM_002827
RefSeq - NM_001278618
RefSeq Peptide - NP_001265547
RefSeq Peptide - NP_002818
swissprot - P18031
swissprot - B4DSN5
swissprot - A8K3M3
Ensembl - ENSG00000196396
  
Related genetic diseases (OMIM): 125853 - {Insulin resistance, susceptibility to}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn1ENSDARG00000007923Danio rerio
 PTPN1ENSGALG00000008010Gallus gallus
 Ptpn1ENSMUSG00000027540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2ENSG0000017535453
PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12ENSG0000012794725
PTPRB / P23467 / protein tyrosine phosphatase, receptor type BENSG0000012732925
PTPN18 / Q99952 / protein tyrosine phosphatase, non-receptor type 18ENSG0000007213524
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG0000016941024
PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type JENSG0000014917723
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149023
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003123
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG0000013424223
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG0000020417921
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response TAS
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009966 regulation of signal transduction IMP
 biological_processGO:0009968 negative regulation of signal transduction TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030100 regulation of endocytosis IDA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0033157 regulation of intracellular protein transport IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IMP
 biological_processGO:0036498 IRE1-mediated unfolded protein response IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway NAS
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IMP
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response TAS
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IDA
 biological_processGO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISS
 biological_processGO:2000646 positive regulation of receptor catabolic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0097443 sorting endosome ISS
 cellular_componentGO:0098554 cytoplasmic side of endoplasmic reticulum membrane IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Negative regulation of MET activity
Regulation of IFNG signaling
PTK6 Down-Regulation
Regulation of IFNA signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / reaction
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / reaction
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / reaction
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction






 

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