ENSG00000159110


Homo sapiens

Features
Gene ID: ENSG00000159110
  
Biological name :IFNAR2
  
Synonyms : IFNAR2 / interferon alpha and beta receptor subunit 2 / P48551
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.11
Gene start: 33229901
Gene end: 33265675
  
Corresponding Affymetrix probe sets: 204785_x_at (Human Genome U133 Plus 2.0 Array)   204786_s_at (Human Genome U133 Plus 2.0 Array)   227125_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402311
Ensembl peptide - ENSP00000403569
Ensembl peptide - ENSP00000413160
Ensembl peptide - ENSP00000384309
Ensembl peptide - ENSP00000398799
Ensembl peptide - ENSP00000343289
Ensembl peptide - ENSP00000343957
Ensembl peptide - ENSP00000371673
Ensembl peptide - ENSP00000371699
NCBI entrez gene - 3455     See in Manteia.
OMIM - 602376
RefSeq - NM_000874
RefSeq - NM_001289126
RefSeq - NM_001289128
RefSeq - NM_207584
RefSeq - NM_207585
RefSeq - NM_001289125
RefSeq Peptide - NP_000865
RefSeq Peptide - NP_001276055
RefSeq Peptide - NP_001276057
RefSeq Peptide - NP_997467
RefSeq Peptide - NP_997468
RefSeq Peptide - NP_001276054
swissprot - P48551
swissprot - C9JCU0
swissprot - C9JM33
swissprot - C9K067
swissprot - F8WDE1
swissprot - H7C176
Ensembl - ENSG00000159110
  
Related genetic diseases (OMIM): 610424 - {Hepatitis B virus, susceptibility to}, 610424
  616669 - ?Immunodeficiency 45, 616669
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNAR2ENSGALG00000041867Gallus gallus
 Ifnar2ENSMUSG00000022971Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP000295.1ENSG00000249624100


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0035455 response to interferon-alpha IMP
 biological_processGO:0035456 response to interferon-beta IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway IMP
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004905 type I interferon receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184979 USP18 / Q9UMW8 / ubiquitin specific peptidase 18  / reaction / complex
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / reaction / complex






 

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