ENSMUSG00000022971


Mus musculus

Features
Gene ID: ENSMUSG00000022971
  
Biological name :Ifnar2
  
Synonyms : Ifnar2 / interferon (alpha and beta) receptor 2 / O35664
  
Possible biological names infered from orthology : AP000295.1 / interferon alpha and beta receptor subunit 2 / P48551
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91372783
Gene end: 91405589
  
Corresponding Affymetrix probe sets: 10436830 (MoGene1.0st)   1427691_a_at (Mouse Genome 430 2.0 Array)   1440169_x_at (Mouse Genome 430 2.0 Array)   1451462_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113358
Ensembl peptide - ENSMUSP00000023693
Ensembl peptide - ENSMUSP00000086443
Ensembl peptide - ENSMUSP00000134796
Ensembl peptide - ENSMUSP00000135322
NCBI entrez gene - 15976     See in Manteia.
MGI - MGI:1098243
RefSeq - XM_011246100
RefSeq - NM_001110498
RefSeq - NM_010509
RefSeq - XM_006522923
RefSeq Peptide - NP_001103968
RefSeq Peptide - NP_001334187
RefSeq Peptide - NP_034639
swissprot - O35664
swissprot - Q923Z6
swissprot - H3BKB3
swissprot - Q9D1R7
swissprot - H3BJ04
Ensembl - ENSMUSG00000022971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNAR2ENSGALG00000041867Gallus gallus
 AP000295.1ENSG00000249624Homo sapiens
 IFNAR2ENSG00000159110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0035455 response to interferon-alpha ISO
 biological_processGO:0035456 response to interferon-beta ISO
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060337 type I interferon signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004905 type I interferon receptor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019962 type I interferon binding ISO


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar2tm1Pjh/Ifnar2tm1Pjh,Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex
 ENSMUSG00000030107 Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*  / reaction / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex






 

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