ENSMUSG00000048806


Mus musculus

Features
Gene ID: ENSMUSG00000048806
  
Biological name :Ifnb1
  
Synonyms : Ifnb1 / interferon beta 1, fibroblast / P01575
  
Possible biological names infered from orthology : interferon beta 1 / P01574
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 88522025
Gene end: 88522774
  
Corresponding Affymetrix probe sets: 10514285 (MoGene1.0st)   1422305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056720
NCBI entrez gene - 15977     See in Manteia.
MGI - MGI:107657
RefSeq - NM_010510
RefSeq Peptide - NP_034640
swissprot - P01575
swissprot - Q0VE17
Ensembl - ENSMUSG00000048806
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNB1ENSG00000171855Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifne / Q80ZF2 / Interferon epsilon / Q86WN2*ENSMUSG0000004536424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000471  Interferon alpha/beta/delta
 IPR009079  Four-helical cytokine-like, core
 IPR015588  Interferon beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IDA
 biological_processGO:0002286 T cell activation involved in immune response IBA
 biological_processGO:0002312 B cell activation involved in immune response ISO
 biological_processGO:0002323 natural killer cell activation involved in immune response IBA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006959 humoral immune response IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030183 B cell differentiation IBA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
 biological_processGO:0035458 cellular response to interferon-beta ISO
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0043330 response to exogenous dsRNA ISO
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045581 negative regulation of T cell differentiation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0060337 type I interferon signaling pathway ISO
 biological_processGO:0071359 cellular response to dsRNA IEP
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:0098586 cellular response to virus IDA
 biological_processGO:2000552 negative regulation of T-helper 2 cell cytokine production ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005132 type I interferon receptor binding IPI
 molecular_functionGO:0008811 chloramphenicol O-acetyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Atcayji/Atcayji
Genetic Background: JIGR

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S2/SvEv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Ifnb1tm1Tl/Ifnb1tm1Tl
Genetic Background: B6.129P2-Ifnb1tm1Tl

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

Allelic Composition: Ifnb1tm1Acgp/Ifnb1tm1Acgp
Genetic Background: B6.129P2-Ifnb1tm1Acgp

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atcayji/Atcayji
Genetic Background: JIGR

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atcayji/Atcayji
Genetic Background: JIGR

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Ifnb1tm2.1Lien/Ifnb1tm2.1Lien,Tyrc-2J/Tyrc-2J,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ifnb1tm1Tl/Ifnb1tm1Tl
Genetic Background: B6.129P2-Ifnb1tm1Tl

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ifnb1tm2.1Lien/Ifnb1tm2.1Lien,Tyrc-2J/Tyrc-2J,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ifnb1tm1Tl/Ifnb1tm1Tl
Genetic Background: B6.129P2-Ifnb1tm1Tl

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Ifnb1tm1Acgp/Ifnb1tm1Acgp
Genetic Background: B6.129P2-Ifnb1tm1Acgp

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr