ENSMUSG00000022967


Mus musculus

Features
Gene ID: ENSMUSG00000022967
  
Biological name :Ifnar1
  
Synonyms : Ifnar1 / Interferon alpha/beta receptor 1 / P33896
  
Possible biological names infered from orthology : interferon alpha and beta receptor subunit 1 / P17181
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91485238
Gene end: 91507441
  
Corresponding Affymetrix probe sets: 10436849 (MoGene1.0st)   1442222_at (Mouse Genome 430 2.0 Array)   1449026_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119160
Ensembl peptide - ENSMUSP00000120945
Ensembl peptide - ENSMUSP00000023689
Ensembl peptide - ENSMUSP00000112670
NCBI entrez gene - 15975     See in Manteia.
MGI - MGI:107658
RefSeq - NM_010508
RefSeq Peptide - NP_034638
swissprot - E9PWM1
swissprot - P33896
Ensembl - ENSMUSG00000022967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il10rbENSDARG00000078042Danio rerio
 IFNAR1ENSGALG00000030363Gallus gallus
 IFNAR1ENSG00000142166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il10rb / Q08334* / interleukin 10 receptor subunit beta*ENSMUSG0000002296912
Ifngr2 / interferon gamma receptor 2 / P38484*ENSMUSG0000002296510
Gm21970 / IL10RB* / Q08334* / interleukin 10 receptor subunit beta*ENSMUSG000000937019


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR016669  Interferon alpha/beta receptor 1
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IGI
 biological_processGO:0035457 cellular response to interferon-alpha IMP
 biological_processGO:0042110 T cell activation IGI
 biological_processGO:0045351 type I interferon biosynthetic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004904 interferon receptor activity IMP
 molecular_functionGO:0004905 type I interferon receptor activity ISO
 molecular_functionGO:0004920 interleukin-10 receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019962 type I interferon binding IPI


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: involves: 129S2/SvPas * BALB/c

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Ifnar1m1Btlr/Ifnar1m1Btlr
Genetic Background: C57BL/6J-Ifnar1m1Btlr

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: involves: 129S2/SvPas * BALB/c

Allelic Composition: Ifnar1m1Btlr/Ifnar1m1Btlr
Genetic Background: C57BL/6J-Ifnar1m1Btlr

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Ifih1Rgsc422/Ifih1+,Ifnar1tm1Agt/Ifnar1+
Genetic Background: involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(Ccr2-GFP)8Pam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnaseh2btm1c(EUCOMM)Wtsi/Rnaseh2btm1c(EUCOMM)Wtsi,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0004795 decreased anti-nuclear antigen antibody level "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1+
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88+
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: B6.129S2-Ifnar1tm1Pjh

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Ifnar1m1Btlr/Ifnar1m1Btlr
Genetic Background: C57BL/6J-Ifnar1m1Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Ifnar1m1Btlr/Ifnar1m1Btlr
Genetic Background: C57BL/6J-Ifnar1m1Btlr

Allelic Composition: Ifnar1m2Btlr/Ifnar1m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Ifnar1tm1Pjh/Ifnar1tm1Pjh
Genetic Background: involves: 129S2/SvPas * BALB/c

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0013155 decreased KLRG1+ CD8 alpha beta T cell number "decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0013691 decreased CD5-positive Ly6C-positive T cell number "reduction in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / reaction / complex
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction / complex
 ENSMUSG00000095498 Ifna1 / P01572 / Interferon alpha-1 / IFNA2* / IFNA5* / IFNA4* / IFNA6* / IFNA7* / IFNA8* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566...  / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex






 

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