ENSMUSG00000022969


Mus musculus

Features
Gene ID: ENSMUSG00000022969
  
Biological name :Il10rb
  
Synonyms : Il10rb
  
Possible biological names infered from orthology : interleukin 10 receptor subunit beta / Q08334
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91406164
Gene end: 91425834
  
Corresponding Affymetrix probe sets: 10436841 (MoGene1.0st)   1419455_at (Mouse Genome 430 2.0 Array)   1429959_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023691
Ensembl peptide - ENSMUSP00000120485
Ensembl peptide - ENSMUSP00000120227
NCBI entrez gene - 16155     See in Manteia.
MGI - MGI:109380
RefSeq - NM_008349
RefSeq - XM_006522924
RefSeq Peptide - NP_032375
swissprot - E9Q294
swissprot - Q8VHM7
swissprot - E9Q083
Ensembl - ENSMUSG00000022969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crfb15ENSDARG00000099342Danio rerio
 crfb4ENSDARG00000068711Danio rerio
 IL10RBENSGALG00000037989Gallus gallus
 IL10RBENSG00000243646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm21970 / IL10RB* / Q08334* / interleukin 10 receptor subunit beta*ENSMUSG0000009370155
Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*ENSMUSG0000002296720
Ifngr2 / interferon gamma receptor 2 / P38484*ENSMUSG0000002296519


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003305 proctitis "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0011224 abnormal lymph node medullary cord morphology "any structural anomaly of the dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" [ISBN:0-683-40008-8]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Oxttm1Ljm/Oxttm1Ljm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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