ENSG00000243646


Homo sapiens

Features
Gene ID: ENSG00000243646
  
Biological name :IL10RB
  
Synonyms : IL10RB / interleukin 10 receptor subunit beta / Q08334
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.11
Gene start: 33266358
Gene end: 33310187
  
Corresponding Affymetrix probe sets: 209575_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414682
Ensembl peptide - ENSP00000489965
Ensembl peptide - ENSP00000489716
Ensembl peptide - ENSP00000290200
Ensembl peptide - ENSP00000397611
NCBI entrez gene - 3588     See in Manteia.
OMIM - 123889
RefSeq - NM_000628
RefSeq Peptide - NP_000619
swissprot - F8WDX2
swissprot - A0A1B0GU52
swissprot - Q08334
swissprot - H7C0Z5
swissprot - A0A1B0GTI5
Ensembl - ENSG00000243646
  
Related genetic diseases (OMIM): 610424 - {Hepatitis B virus, susceptibility to}, 610424
  612567 - Inflammatory bowel disease 25, early onset, autosomal recessive, 612567
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crfb15ENSDARG00000099342Danio rerio
 crfb4ENSDARG00000068711Danio rerio
 IL10RBENSGALG00000037989Gallus gallus
 Gm21970ENSMUSG00000093701Mus musculus
 Il10rbENSMUSG00000022969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNGR2 / P38484 / interferon gamma receptor 2ENSG0000015912825
IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1ENSG0000014216623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032002 interleukin-28 receptor complex NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004920 interleukin-10 receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Other interleukin signaling
Interleukin-10 signaling
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000143 Rectovaginal fistula "The presence of a fistula between the rectum and the vagina." [HPO:curators]
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 HP:0004387 Enterocolitis 
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 HP:0005224 Rectal abscess 
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 HP:0009789 Perianal abscess "The presence of an abscess located around the anus." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110324 IL10RA / Q13651 / interleukin 10 receptor subunit alpha  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000183709 IFNL2 / Q8IZJ0 / interferon lambda 2  / complex
 ENSG00000016402 IL20RA / Q9UHF4 / interleukin 20 receptor subunit alpha  / complex / reaction
 ENSG00000111536 IL26 / Q9NPH9 / interleukin 26  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000185436 IFNLR1 / Q8IU57 / interferon lambda receptor 1  / reaction / complex
 ENSG00000142677 Q8N6P7 / IL22RA1 / interleukin 22 receptor subunit alpha 1  / reaction / complex
 ENSG00000197110 IFNL3 / Q8IZI9 / interferon lambda 3  / complex
 ENSG00000136634 IL10 / P22301 / interleukin 10  / complex / reaction
 ENSG00000182393 IFNL1 / Q8IU54 / interferon lambda 1  / reaction / complex
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / reaction / complex
 ENSG00000127318 IL22 / Q9GZX6 / interleukin 22  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex






 

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