ENSG00000110324


Homo sapiens

Features
Gene ID: ENSG00000110324
  
Biological name :IL10RA
  
Synonyms : IL10RA / interleukin 10 receptor subunit alpha / Q13651
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 117986348
Gene end: 118003037
  
Corresponding Affymetrix probe sets: 204912_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227752
Ensembl peptide - ENSP00000436328
Ensembl peptide - ENSP00000435317
NCBI entrez gene - 3587     See in Manteia.
OMIM - 146933
RefSeq - NM_001558
RefSeq Peptide - NP_001549
swissprot - E9PPU4
swissprot - E9PKU2
swissprot - Q13651
Ensembl - ENSG00000110324
  
Related genetic diseases (OMIM): 613148 - Inflammatory bowel disease 28, early onset, autosomal recessive, 613148
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL10RAENSGALG00000032260Gallus gallus
 Il10raENSMUSG00000032089Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0050807 regulation of synapse organization IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0004920 interleukin-10 receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019969 interleukin-10 binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0000999 Pyoderma 
Show

 HP:0002573 Hematochezia 
Show

 HP:0004387 Enterocolitis 
Show

 HP:0009789 Perianal abscess "The presence of an abscess located around the anus." [HPO:curators]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / complex / reaction
 ENSG00000110324 IL10RA / Q13651 / interleukin 10 receptor subunit alpha  / reaction / complex
 ENSG00000136634 IL10 / P22301 / interleukin 10  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr