ENSMUSG00000032089


Mus musculus

Features
Gene ID: ENSMUSG00000032089
  
Biological name :Il10ra
  
Synonyms : Il10ra / Interleukin-10 receptor subunit alpha / Q61727
  
Possible biological names infered from orthology : Q13651
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 45253837
Gene end: 45269149
  
Corresponding Affymetrix probe sets: 10593050 (MoGene1.0st)   1437808_x_at (Mouse Genome 430 2.0 Array)   1448731_at (Mouse Genome 430 2.0 Array)   1456173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034594
Ensembl peptide - ENSMUSP00000135361
Ensembl peptide - ENSMUSP00000135461
NCBI entrez gene - 16154     See in Manteia.
MGI - MGI:96538
RefSeq - NM_001324486
RefSeq - NM_008348
RefSeq Peptide - NP_001311415
RefSeq Peptide - NP_032374
swissprot - Q61727
swissprot - H3BKE8
swissprot - Q3UDL4
swissprot - H3BKN6
Ensembl - ENSMUSG00000032089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL10RAENSGALG00000032260Gallus gallus
 IL10RAENSG00000110324Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0050807 regulation of synapse organization IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004920 interleukin-10 receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019969 interleukin-10 binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Vsig4tm1Gne/Vsig4tm1Gne,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008638 increased circulating interleukin-1 alpha level "increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000016529 Il10 / P18893 / Interleukin-10 / P22301*  / complex / reaction
 ENSMUSG00000032089 Il10ra / Q61727 / Interleukin-10 receptor subunit alpha / Q13651*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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