ENSMUSG00000028530


Mus musculus

Features
Gene ID: ENSMUSG00000028530
  
Biological name :Jak1
  
Synonyms : Jak1 / Janus kinase 1
  
Possible biological names infered from orthology : P23458
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C6
Gene start: 101152367
Gene end: 101265282
  
Corresponding Affymetrix probe sets: 10514668 (MoGene1.0st)   1433803_at (Mouse Genome 430 2.0 Array)   1433804_at (Mouse Genome 430 2.0 Array)   1433805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099842
Ensembl peptide - ENSMUSP00000122957
NCBI entrez gene - 16451     See in Manteia.
MGI - MGI:96628
RefSeq - NM_146145
RefSeq - XM_006502812
RefSeq - XM_011240451
RefSeq Peptide - NP_666257
swissprot - B1ASP3
swissprot - B1ASP2
Ensembl - ENSMUSG00000028530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak1ENSDARG00000020625Danio rerio
 JAK1ENSGALG00000011031Gallus gallus
 JAK1ENSG00000162434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tyk2 / tyrosine kinase 2 / P29597*ENSMUSG0000003217545
Jak2 / Janus kinase 2 / O60674*ENSMUSG0000002478941
Jak3 / Janus kinase 3 / P52333*ENSMUSG0000003180537


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020776  Tyrosine-protein kinase, non-receptor Jak1
 IPR035963  FERM superfamily, second domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038110 interleukin-2-mediated signaling pathway IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0004945 abnormal bone resorption "anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005328 abnormal circulating creatinine level "anomalous blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005516 increased liver regeneration "greater than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Jak1tm1.1Kuw/Jak1tm1.1Kuw
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Jak1tm1Kuw/Jak1tm1Kuw,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008956 decreased cellular hemoglobin content "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0010965 decreased compact bone volume 
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Jak1tm1.1Kuw/Jak1tm1.1Kuw
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0011584 increased alkaline phosphatase activity "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / reaction / complex
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / complex / reaction
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / complex / reaction
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000016524 Il19 / Q8CJ70 / Interleukin-19 / Q9UHD0*  / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / complex
 ENSMUSG00000016529 Il10 / P18893 / Interleukin-10 / P22301*  / complex / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / complex / reaction
 ENSMUSG00000026416 Il20 / Q9JKV9 / interleukin 20 / Q9NYY1*  / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / complex
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / complex
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000022146 Osmr / oncostatin M receptor / Q99650*  / complex / reaction
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000034394 Lif / P09056 / Leukemia inhibitory factor / P15018* / LIF, interleukin 6 family cytokine*  / reaction / complex
 ENSMUSG00000032089 Il10ra / Q61727 / Interleukin-10 receptor subunit alpha / Q13651*  / complex / reaction
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex / reaction
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / complex
 ENSMUSG00000029437 Il31 / Q6EAL8 / Interleukin-31 / Q6EBC2*  / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / complex / reaction
 ENSMUSG00000042340 Ctf1 / Q60753 / Cardiotrophin-1 / Q16619*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / reaction / complex
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex / reaction
 ENSMUSG00000040663 Clcf1 / Q9QZM3 / Cardiotrophin-like cytokine factor 1 / Q9UBD9*  / complex / reaction
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000050377 Il31ra / Q8K5B1 / Interleukin-31 receptor subunit alpha / Q8NI17* / interleukin 31 receptor A*  / complex
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / complex / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / complex / reaction
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000023206 Il15ra / Q60819 / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q13261* / interleukin 15 receptor subunit alpha*  / complex
 ENSMUSG00000062157 Ifnlr1 / Q8CGK5 / Interferon lambda receptor 1 / Q8IU57*  / complex / reaction
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / reaction / complex
 ENSMUSG00000026420 Il24 / interleukin 24 / Q13007*  / complex
 ENSMUSG00000060747 Ifnl3 / Q8CGK6 / Interferon lambda-3 / IFNL2* / Q8IZI9* / Q8IZJ0* / interferon lambda 2*  / complex
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000058755 Osm / P53347 / Oncostatin-M / P13725*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex
 ENSMUSG00000078735 P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000073889 Q64385 / Il11ra1 / Interleukin-11 receptor subunit alpha-1 / IL11RA* / Q14626* / interleukin 11 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000004371 Il11 / P47873 / Interleukin-11 / P20809*  / reaction / complex
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000020007 Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000059128 Ifnl2 / Q4VK74 / Interferon lambda-2 / IFNL3* / Q8IZJ0* / Q8IZI9* / interferon lambda 3*  / complex
 ENSMUSG00000044244 Il20rb / interleukin 20 receptor subunit beta / Q6UXL0*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex
 ENSMUSG00000079415 Cntf / P51642 / Ciliary neurotrophic factor / P26441*  / reaction / complex
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / complex / reaction






 

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