ENSMUSG00000025746


Mus musculus

Features
Gene ID: ENSMUSG00000025746
  
Biological name :Il6
  
Synonyms : Il6 / interleukin 6 / P08505
  
Possible biological names infered from orthology : P05231
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30013114
Gene end: 30019981
  
Corresponding Affymetrix probe sets: 10520452 (MoGene1.0st)   1450297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026845
Ensembl peptide - ENSMUSP00000143544
Ensembl peptide - ENSMUSP00000143293
Ensembl peptide - ENSMUSP00000143157
NCBI entrez gene - 16193     See in Manteia.
MGI - MGI:96559
RefSeq - NM_001314054
RefSeq - NM_031168
RefSeq Peptide - NP_001300983
RefSeq Peptide - NP_112445
swissprot - P08505
swissprot - A0A0G2JGF4
swissprot - A0A0G2JFT1
swissprot - A0A0G2JFG1
swissprot - A2RTD1
Ensembl - ENSMUSG00000025746
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL6ENSGALG00000010915Gallus gallus
 IL6ENSG00000136244Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003574  Interleukin-6
 IPR009079  Four-helical cytokine-like, core
 IPR030473  Interleukin-6/GCSF/MGF, conserved site
 IPR030474  Interleukin-6/GCSF/MGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001781 neutrophil apoptotic process ISO
 biological_processGO:0001878 response to yeast IEA
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0002384 hepatic immune response ISO
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002675 positive regulation of acute inflammatory response ISO
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production ISO
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0031294 lymphocyte costimulation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0042110 T cell activation IGI
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process IMP
 biological_processGO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045721 negative regulation of gluconeogenesis IEA
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0045837 negative regulation of membrane potential IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046427 positive regulation of JAK-STAT cascade ISO
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IGI
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0046888 negative regulation of hormone secretion IDA
 biological_processGO:0048635 negative regulation of muscle organ development IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050710 negative regulation of cytokine secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050871 positive regulation of B cell activation ISO
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051384 response to glucocorticoid ISO
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IEA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IMP
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IDA
 biological_processGO:0070091 glucagon secretion IMP
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IGI
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1990646 cellular response to prolactin IEA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005896 interleukin-6 receptor complex ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Il6tm1.1Jho/Il6+,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ahvy/Ahvy
Genetic Background: B6.C3-Bpifa2a Ahvy

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Galctwi/Galctwi,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002336 abnormal pulmonary gas exchange "anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002433 abnormal T helper 1 morphology/development "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: involves: BALB/cJ

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0003278 esophageal inflammation "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: (C3H/HeN x C57BL/6J)F1

Allelic Composition: Il6tm1Kopf/Il6+,Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic Background: B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il6tm1Kopf/Il6+,Ncoa5tm1Hxia/Ncoa5+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npc1m1N/Npc1m1N,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nefmtm1Ral/Nefmtm1Ral
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster)

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nefmtm1Ral/Nefmtm1Ral
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: CAnNCrl.129S(Cg)-Il6tm1Poli

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Galctwi/Galctwi,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008046 absent NK cells "absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm1Kuch/?,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Foxp3tm1Kuch/?,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Foxp3tm1Kuch/?,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0008704 abnormal interleukin-6 secretion "anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Galctwi/Galctwi,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0009410 abnormal skeletal muscle satellite cell proliferation "anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009753 enhanced behavioral response to morphine "increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * MF1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0009978 abnormal cerebellum white matter morphology 
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Allelic Composition: Galctwi/Galctwi,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Il6+/?
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0010119 abnormal bone mineral density "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0010211 abnormal acute phase protein level "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Il6tm1Kopf/Il6+,Ncoa5tm1Hxia/Ncoa5+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Il6tm1.1Jho/Il6tm1.1Jho,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
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Allelic Composition: Il6tm1Mur/Il6tm1Mur
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0030587 abnormal pancreatic alpha cell mass "anomaly in the total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.129S2-Il6tm1Kopf/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex






 

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