16193


Mus musculus (NCBI)
regulationcellresponseprocessproliferationinterleukin-cellularapoptoticproteinactivityfactorsignalinghomeostasisproductionneurondevelopmentsecretiongrowthpathwaybiosyntheticphosphorylationinvolvedcascadet-helpertranscriptionmusclecytokinereceptorbindingimmune

Features
Gene ID: 16193
  
Biological name :
  
Synonyms : Il6 / interleukin 6
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1450297_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - NP_001300983.1
RefSeq - NP_112445.1
RefSeq - NC_000071.6
RefSeq - 13624311
RefSeq - 930945756
RefSeq - NM_001314054.1
RefSeq - NM_031168.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000025746 to get all the annotations available for this gene.


Gene Ontology (GO)
regulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregulation of biological qualitycell deathimmune responseresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular component organizationanatomical structure developmentcellular developmental processcytokine productioncell communicationresponse to chemicalcellular response to stimulusbiosynthetic processcollagen metabolic processmacromolecule localizationestablishment of localizationcellular localizationcell activationcell adhesionleukocyte proliferationresponse to biotic stimulusrhythmic behaviorsleepcircadian rhythmimmune effector processsmall molecule metabolic processtissue remodelingmuscle cell proliferationepithelial cell proliferationproduction of molecular mediator of immune responseresponse to endogenous stimulussystem processmulticellular organismal signalingcell proliferation in bone marrowregregulation of biological qualitycelcell deathimmimmune responseresresponse to stressresresponse to external stimulusnitnitrogen compound metabolic processcelcellular metabolic processpriprimary metabolic processregregulation of molecular functionorgorganic substance metabolic processcelcellular component organizationanaanatomical structure developmentcelcellular developmental processcytcytokine productioncelcell communicationresresponse to chemicalcelcellular response to stimulusbiobiosynthetic processcolcollagen metabolic processmacmacromolecule localizationestestablishment of localizationcelcellular localizationcelcell activationcelcell adhesionleuleukocyte proliferationresresponse to biotic stimulusrhyrhythmic behaviorslesleepcircircadian rhythmimmimmune effector processsmasmall molecule metabolic processtistissue remodelingmusmuscle cell proliferationepiepithelial cell proliferationproproduction of molecular mediator of immune responseresresponse to endogenous stimulussyssystem processmulmulticellular organismal signalingcelcell proliferation in bone marrow
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regionextracellular regioncellcellmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001781 neutrophil apoptotic process ISO
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0002384 hepatic immune response ISO
 biological_processGO:0002675 positive regulation of acute inflammatory response ISO
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0032966 negative regulation of collagen biosynthetic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation ISO
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0042110 T cell activation IGI
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process IMP
 biological_processGO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045454 cell redox homeostasis ISO
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation ISO
 biological_processGO:0045721 negative regulation of gluconeogenesis ISO
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045740 positive regulation of DNA replication ISO
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0045837 negative regulation of membrane potential ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046427 positive regulation of JAK-STAT cascade ISO
 biological_processGO:0046716 muscle cell cellular homeostasis IGI
 biological_processGO:0046888 negative regulation of hormone secretion IDA
 biological_processGO:0048635 negative regulation of muscle organ development ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050710 negative regulation of cytokine secretion ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050871 positive regulation of B cell activation ISO
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051384 response to glucocorticoid ISO
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0051971 positive regulation of transmission of nerve impulse ISO
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IMP
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IDA
 biological_processGO:0070091 glucagon secretion IMP
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IGI
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 biological_processGO:1901215 negative regulation of neuron death ISO
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005896 interleukin-6 receptor complex ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005138 interleukin-6 receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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