ENSMUSG00000034342


Mus musculus

Features
Gene ID: ENSMUSG00000034342
  
Biological name :Cbl
  
Synonyms : Cbl / E3 ubiquitin-protein ligase CBL / P22682
  
Possible biological names infered from orthology : Cbl proto-oncogene / P22681
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44142976
Gene end: 44234049
  
Corresponding Affymetrix probe sets: 10592734 (MoGene1.0st)   1434829_at (Mouse Genome 430 2.0 Array)   1450457_at (Mouse Genome 430 2.0 Array)   1455886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041902
Ensembl peptide - ENSMUSP00000146287
Ensembl peptide - ENSMUSP00000146244
Ensembl peptide - ENSMUSP00000145889
Ensembl peptide - ENSMUSP00000145827
Ensembl peptide - ENSMUSP00000145791
Ensembl peptide - ENSMUSP00000145538
NCBI entrez gene - 12402     See in Manteia.
MGI - MGI:88279
RefSeq - XM_017313115
RefSeq - NM_007619
RefSeq - XM_006509963
RefSeq Peptide - NP_031645
swissprot - A0A0U1RNF1
swissprot - A0A0U1RQ85
swissprot - A0A0X1KG61
swissprot - P22682
swissprot - A0A0U1RP95
swissprot - A0A0U1RP17
swissprot - A0A0U1RP47
Ensembl - ENSMUSG00000034342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cblENSDARG00000009958Danio rerio
 CBLENSGALG00000029077Gallus gallus
 CBLENSG00000110395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cblb / Q3TTA7 / E3 ubiquitin-protein ligase CBL-B / Q13191* / Cbl proto-oncogene B*ENSMUSG0000002263750
Cblc / Q80XL1 / E3 ubiquitin-protein ligase CBL-C / Q9ULV8* / Cbl proto-oncogene C*ENSMUSG0000004052523


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR009060  UBA-like superfamily
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl
 IPR036537  Adaptor protein Cbl, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IBA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0045453 bone resorption ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0070997 neuron death IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016600 flotillin complex IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cbltm1Soga/Cbltm1Soga
Genetic Background: Not Specified

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Cbltm1Soga/Cbltm1Soga,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lattm1Les/Lattm1Les
Genetic Background: involves: 129P2/OlaHsd

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Disc1tm1Kara/Disc1+
Genetic Background: B6.129S6-Disc1tm1Kara

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Suz/Psaptm1Suz
Genetic Background: involves: 129P2/OlaHsd

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disc1tm1Kara/Disc1+
Genetic Background: B6.129S6-Disc1tm1Kara

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lattm1Les/Lattm1Les
Genetic Background: involves: 129P2/OlaHsd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lattm1Les/Lattm1Les
Genetic Background: involves: 129P2/OlaHsd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lattm1Les/Lattm1Les
Genetic Background: involves: 129P2/OlaHsd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Cbltm1Soga/Cbltm1Soga,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Cbltm1Soga/Cbl+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002364 abnormal thymus size "deviation from the normal size of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry1tm1Bhk/P2ry1tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Soga/Cbltm1Soga
Genetic Background: Not Specified

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbl+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cbltm1Ddlb/Cbl+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lcp2tm1Gak/Lcp2tm1Gak
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cbltm1.1Hua/Cbltm1.1Hua,Lattm1Les/Lattm1Les
Genetic Background: involves: 129P2/OlaHsd

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008904 abnormal mammary fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009069 dilated oviduct "an expansion in the volume or area of the tube through which the ova pass from the ovary to the uterus, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009379 abnormal foot pigmentation "anomaly in the coloration of the foot" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: Cbltm2Wlan/Cbltm2Wlan
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cbltm1Ddlb/Cbltm2Wlan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Cbltm1Ddlb/Cbltm1Ddlb
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001036 Epn2 / Q8CHU3 / Epsin-2 / O95208*  / reaction / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / reaction
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex / reaction
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / reaction / complex
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction / complex
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction / complex
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction / complex
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction / complex
 ENSMUSG00000037211 Spry1 / Q9QXV9 / sprouty RTK signaling antagonist 1 / O43609*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000035203 Epn1 / Q80VP1 / Epsin-1 / Q9Y6I3*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / complex / reaction






 

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