ENSMUSG00000037211


Mus musculus

Features
Gene ID: ENSMUSG00000037211
  
Biological name :Spry1
  
Synonyms : Q9QXV9 / sprouty RTK signaling antagonist 1 / Spry1
  
Possible biological names infered from orthology : O43609
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 37639947
Gene end: 37644598
  
Corresponding Affymetrix probe sets: 10491721 (MoGene1.0st)   1415874_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049292
Ensembl peptide - ENSMUSP00000103742
Ensembl peptide - ENSMUSP00000103744
NCBI entrez gene - 24063     See in Manteia.
MGI - MGI:1345139
RefSeq - NM_001305442
RefSeq - NM_001305440
RefSeq - NM_001305441
RefSeq - NM_011896
RefSeq Peptide - NP_001292369
RefSeq Peptide - NP_001292370
RefSeq Peptide - NP_001292371
RefSeq Peptide - NP_036026
swissprot - Q53ZU1
swissprot - Q9QXV9
Ensembl - ENSMUSG00000037211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry1ENSDARG00000103985Danio rerio
 SPRY1ENSGALG00000042067Gallus gallus
 SPRY1ENSG00000164056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*ENSMUSG0000002211454
4 / Spry4 / Q9WTP2 / Q9C004* / sprouty RTK signaling antagonist 4*ENSMUSG0000002442737


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030783  Protein sprouty homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IGI
 biological_processGO:0001656 metanephros development IGI
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IDA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IDA
 biological_processGO:0060449 bud elongation involved in lung branching IGI
 biological_processGO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IGI
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
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Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Spry1tm1.1Jdli/Spry1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0003605 fused kidneys 
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010981 abnormal branching involved in ureteric bud morphogenesis "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011486 ectopic ureter "an abnormally placed opening of the ureter, either into the urinary bladder or at another site in the lower urinary or genital tract" [MGI:anna]
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Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011760 abnormal ureteric bud tip morphology "any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011761 abnormal ureteric bud trunk morphology "any structural anomaly of the ureteric bud cells that elongate to form a rigid structure (stalk) consisting of polarized epithelial cells without branching; the stalks differentiate into the collecting system of the mature kidney, while the tip cells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into nephrons" [MGI:anna]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011797 blind ureter "a ureter ending in a blind-ended segment or pouch" [MGI:anna]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction






 

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