ENSDARG00000103985


Danio rerio

Features
Gene ID: ENSDARG00000103985
  
Biological name :spry1
  
Synonyms : sprouty homolog 1, antagonist of FGF signaling (Drosophila) / spry1
  
Possible biological names infered from orthology : O43609 / Q9QXV9 / sprouty RTK signaling antagonist 1
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 497695
Gene end: 498979
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000135575
NCBI entrez gene - 798229     See in Manteia.
RefSeq - NM_001122600
RefSeq Peptide - NP_001116072
swissprot - B1PBZ7
ZFIN ID - ZDB-GENE-081215-2
Ensembl - ENSDARG00000103985
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPRY1ENSGALG00000042067Gallus gallus
 SPRY1ENSG00000164056Homo sapiens
 Spry1ENSMUSG00000037211Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spry2 / sprouty RTK signaling antagonist 2 / O43597* / Q9QXV8*ENSDARG0000007830837
spry4 / sprouty homolog 4 (Drosophila) / Q9C004* / sprouty RTK signaling antagonist 4*ENSDARG0000006873232


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030783  Protein sprouty homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0016020 membrane IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000132 neural plate neural plate decreased length , abnormal
neural plate increased width , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex






 

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