ENSG00000164056


Homo sapiens

Features
Gene ID: ENSG00000164056
  
Biological name :SPRY1
  
Synonyms : O43609 / sprouty RTK signaling antagonist 1 / SPRY1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q28.1
Gene start: 123396795
Gene end: 123403760
  
Corresponding Affymetrix probe sets: 212558_at (Human Genome U133 Plus 2.0 Array)   230212_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421036
Ensembl peptide - ENSP00000481675
Ensembl peptide - ENSP00000480540
Ensembl peptide - ENSP00000425946
Ensembl peptide - ENSP00000421622
Ensembl peptide - ENSP00000343785
Ensembl peptide - ENSP00000377871
NCBI entrez gene - 10252     See in Manteia.
OMIM - 602465
RefSeq - XM_017007635
RefSeq - NM_001258038
RefSeq - NM_001258039
RefSeq - NM_005841
RefSeq - NM_199327
RefSeq - XM_005262686
RefSeq Peptide - NP_001244968
RefSeq Peptide - NP_005832
RefSeq Peptide - NP_955359
RefSeq Peptide - NP_001244967
swissprot - O43609
swissprot - D6REX7
swissprot - D6RHD2
swissprot - D6RIE6
Ensembl - ENSG00000164056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry1ENSDARG00000103985Danio rerio
 SPRY1ENSGALG00000042067Gallus gallus
 Spry1ENSMUSG00000037211Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPRY2 / O43597 / sprouty RTK signaling antagonist 2ENSG0000013615855
SPRY3 / O43610 / sprouty RTK signaling antagonist 3ENSG0000016893938
SPRY4 / Q9C004 / sprouty RTK signaling antagonist 4ENSG0000018767837


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030783  Protein sprouty homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 biological_processGO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex






 

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