ENSG00000136158


Homo sapiens

Features
Gene ID: ENSG00000136158
  
Biological name :SPRY2
  
Synonyms : O43597 / sprouty RTK signaling antagonist 2 / SPRY2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q31.1
Gene start: 80335976
Gene end: 80340951
  
Corresponding Affymetrix probe sets: 204011_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366306
Ensembl peptide - ENSP00000366308
NCBI entrez gene - 10253     See in Manteia.
OMIM - 602466
RefSeq - NM_001318538
RefSeq - NM_001318536
RefSeq - NM_001318537
RefSeq - NM_005842
RefSeq Peptide - NP_001305465
RefSeq Peptide - NP_001305466
RefSeq Peptide - NP_001305467
RefSeq Peptide - NP_005833
swissprot - O43597
Ensembl - ENSG00000136158
  
Related genetic diseases (OMIM): 616818 - {?IgA nephropathy, susceptibility to, 3}, 616818
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry2ENSDARG00000078308Danio rerio
 SPRY2ENSGALG00000016906Gallus gallus
 Spry2ENSMUSG00000022114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPRY1 / O43609 / sprouty RTK signaling antagonist 1ENSG0000016405656
SPRY3 / O43610 / sprouty RTK signaling antagonist 3ENSG0000016893941
SPRY4 / Q9C004 / sprouty RTK signaling antagonist 4ENSG0000018767835


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030780  Protein sprouty homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031345 negative regulation of cell projection organization ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060437 lung growth IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 biological_processGO:0060541 respiratory system development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton ISS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IC
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IMP


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104695 P62714 / PPP2CB / protein phosphatase 2 catalytic subunit beta  / complex
 ENSG00000113575 P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alpha  / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000105568 P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit Aalpha  / complex
 ENSG00000079277 MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1  / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / complex






 

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