ENSGALG00000016906


Gallus gallus

Features
Gene ID: ENSGALG00000016906
  
Biological name :SPRY2
  
Synonyms : protein sprouty homolog 2 / SPRY2
  
Possible biological names infered from orthology : O43597 / Q9QXV8 / sprouty RTK signaling antagonist 2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 152670026
Gene end: 152675345
  
Corresponding Affymetrix probe sets: Gga.3374.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027276
NCBI entrez gene - 395584     See in Manteia.
RefSeq - XM_015275123
RefSeq - NM_204800
RefSeq - XM_015275115
RefSeq - XM_015275119
RefSeq Peptide - NP_990131
swissprot - F1NZG9
Ensembl - ENSGALG00000016906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry2ENSDARG00000078308Danio rerio
 SPRY2ENSG00000136158Homo sapiens
 Spry2ENSMUSG00000022114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPRY1 / sprouty RTK signaling antagonist 1 / O43609* / Q9QXV9*ENSGALG0000004206755
SPRY3 / sprouty RTK signaling antagonist 3 / O43610*ENSGALG0000000744840
SPRY4 / sprouty RTK signaling antagonist 4 / 4 * / Q9C004* / Q9WTP2*ENSGALG0000003301239


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030780  Protein sprouty homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031345 negative regulation of cell projection organization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060437 lung growth IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 biological_processGO:0060541 respiratory system development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000006462 PPP2CA / protein phosphatase 2 catalytic subunit alpha / P63330* / P67775* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000010273 P48463 / PPP2CB / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein pho...  / complex






 

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