Manteia

ENSGALG00000006462

Gallus gallus

Features

Gene ID:	ENSGALG00000006462

Biological name :	PPP2CA

Synonyms :	PPP2CA / protein phosphatase 2 catalytic subunit alpha

Possible biological names infered from orthology :	P63330 / P67775 / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Species:	Gallus gallus

Chr. number:	13
Strand:	1
Band:
Gene start:	15972376
Gene end:	15988375

Corresponding Affymetrix probe sets:	Gga.8891.1.S1_s_at (Chicken Array) GgaAffx.11640.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000058695 Ensembl peptide - ENSGALP00000063709 Ensembl peptide - ENSGALP00000063232 Ensembl peptide - ENSGALP00000010423 NCBI entrez gene - 416318 See in Manteia. RefSeq - NM_001006152 RefSeq Peptide - NP_001006152 swissprot - A0A1L1RXY0 swissprot - A0A1L1RIW9 swissprot - Q5ZM47 Ensembl - ENSGALG00000006462

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P48463 / PPP2CB / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein pho...	ENSGALG00000010273	98

Protein motifs (from Interpro)

Interpro ID	Name
IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052	Metallo-dependent phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0007498	mesoderm development	IEA
biological_process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IEA
biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	IEA
cellular_component	GO:0000159	protein phosphatase type 2A complex	IEA
cellular_component	GO:0000775	chromosome, centromeric region	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0008022	protein C-terminus binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0050811	GABA receptor binding	IEA

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000004821	PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ reaction
ENSGALG00000003855	SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*	/ reaction
ENSGALG00000008016	GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*	/ reaction / complex
ENSGALG00000000235	PPP2R2A / protein phosphatase 2 regulatory subunit Balpha / P63151* / Q6P1F6* / protein phosphatase 2, regulatory subunit B, alpha*	/ complex
ENSGALG00000016906	SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr