ENSDARG00000053404


Danio rerio

Features
Gene ID: ENSDARG00000053404
  
Biological name :PPP2CA
  
Synonyms : PPP2CA / zgc:56064
  
Possible biological names infered from orthology : P63330 / P67775 / protein phosphatase 2 catalytic subunit alpha / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 45351660
Gene end: 45363956
  
Corresponding Affymetrix probe sets: Dr.19474.1.S1_at (Zebrafish Array)   NM_200911_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000069926
Ensembl peptide - ENSDARP00000125818
Ensembl peptide - ENSDARP00000152562
NCBI entrez gene - 393885     See in Manteia.
RefSeq - NM_200911
RefSeq Peptide - NP_957205
swissprot - F1Q6Z7
ZFIN ID - ZDB-GENE-040426-877
Ensembl - ENSDARG00000053404
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP2CAENSGALG00000006462Gallus gallus
 P67775ENSG00000113575Homo sapiens
 P63330ENSMUSG00000020349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ppp2cb / protein phosphatase 2, catalytic subunit, beta isozyme / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein phosphatase 2A catalytic subun...ENSDARG0000009924196
ppp2ca / protein phosphatase 2, catalytic subunit, alpha isozymeENSDARG0000003022494
ppp4ca / A8WGP3 / protein phosphatase 4, catalytic subunit a / PPP4C* / P97470* / P60510* / protein phosphatase 4 catalytic subunit*ENSDARG0000007057063
ppp4cb / A9JRC7 / protein phosphatase 4, catalytic subunit b / PPP4C* / P97470* / P60510* / protein phosphatase 4 catalytic subunit*ENSDARG0000007643963


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006624 ppp2r2ab / protein phosphatase 2, regulatory subunit B, alpha b / Q6P1F6* / P63151* / PPP2R2A* / protein phosphatase 2 regulatory subunit Balpha* / protein phosphatase 2, regulatory subunit B, alpha*  / complex
 ENSDARG00000078308 spry2 / sprouty RTK signaling antagonist 2 / O43597* / Q9QXV8*  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000021996 ppp2r2aa / protein phosphatase 2, regulatory subunit B, alpha a / P63151* / PPP2R2A* / protein phosphatase 2 regulatory subunit Balpha*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex






 

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