ENSDARG00000078308


Danio rerio

Features
Gene ID: ENSDARG00000078308
  
Biological name :spry2
  
Synonyms : sprouty RTK signaling antagonist 2 / spry2
  
Possible biological names infered from orthology : O43597 / Q9QXV8
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 5273481
Gene end: 5277583
  
Corresponding Affymetrix probe sets: Dr.10361.1.A1_at (Zebrafish Array)   Dr.13009.1.A1_at (Zebrafish Array)   Dr.13009.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000052422
Ensembl peptide - ENSDARP00000151098
NCBI entrez gene - 335098     See in Manteia.
RefSeq - XM_005160285
swissprot - F1QU39
ZFIN ID - ZDB-GENE-030131-7038
Ensembl - ENSDARG00000078308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPRY2ENSGALG00000016906Gallus gallus
 SPRY2ENSG00000136158Homo sapiens
 Spry2ENSMUSG00000022114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spry1 / sprouty homolog 1, antagonist of FGF signaling (Drosophila) / O43609* / sprouty RTK signaling antagonist 1*ENSDARG0000010398536
spry4 / sprouty homolog 4 (Drosophila) / Q9C004* / sprouty RTK signaling antagonist 4*ENSDARG0000006873233


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030780  Protein sprouty homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0060841 venous blood vessel development IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000132 neural plate neural plate decreased length , abnormal
neural plate increased width , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex
 ENSDARG00000099241 ppp2cb / protein phosphatase 2, catalytic subunit, beta isozyme / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein phosphatase 2A catalytic subun...  / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex
 ENSDARG00000053404 PPP2CA / zgc:56064 / P67775* / P63330* / protein phosphatase 2 catalytic subunit alpha* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex






 

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