ENSMUSG00000022114


Mus musculus

Features
Gene ID: ENSMUSG00000022114
  
Biological name :Spry2
  
Synonyms : Q9QXV8 / sprouty RTK signaling antagonist 2 / Spry2
  
Possible biological names infered from orthology : O43597
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.3
Gene start: 105891947
Gene end: 105896819
  
Corresponding Affymetrix probe sets: 10422227 (MoGene1.0st)   1421656_at (Mouse Genome 430 2.0 Array)   1436584_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022709
NCBI entrez gene - 24064     See in Manteia.
MGI - MGI:1345138
RefSeq - XM_006519016
RefSeq - NM_011897
RefSeq Peptide - NP_036027
swissprot - Q9QXV8
swissprot - B2RS85
Ensembl - ENSMUSG00000022114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry2ENSDARG00000078308Danio rerio
 SPRY2ENSGALG00000016906Gallus gallus
 SPRY2ENSG00000136158Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spry1 / Q9QXV9 / sprouty RTK signaling antagonist 1 / O43609*ENSMUSG0000003721154
4 / Spry4 / Q9WTP2 / Q9C004* / sprouty RTK signaling antagonist 4*ENSMUSG0000002442737


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030780  Protein sprouty homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISO
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031345 negative regulation of cell projection organization IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IDA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060425 lung morphogenesis IDA
 biological_processGO:0060437 lung growth IDA
 biological_processGO:0060449 bud elongation involved in lung branching IGI
 biological_processGO:0060541 respiratory system development IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
Show

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0003825 abnormal pillar cell morphology "abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1+,Spry2tm1.1Mrt/Spry2tm1.1Mrt
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004300 abnormal supporting cell morphology "any structural abnormality in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0004430 abnormal Claudius cell morphology "any structural abnormality in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos
Genetic Background: B6.Cg-Spry2tm1Ayos

 MP:0004840 increased Dieters cell number "increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4.1Tyj/Kras+,Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009652 abnormal palatal rugae "any structural anomaly in the transversal ridges that develop on the secondary (hard) palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011028 impaired branching involved in bronchus morphogenesis 
Show

Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Atp8a2wl-vmd/Atp8a2wl-vmd
Genetic Background: C3H/HeSnJ-Atp8a2wl-vmd/J

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0030536 abnormal diastema morphology "any anomaly of the space or gap between two adjacent teeth in the same dental arch; in rodents, the diastema is the toothless (edentulous) region that normally separates a continuously growing single incisor from a segment of three molars in each quadrant of the adult jaw; although tooth primordia develop in the rodent embryonic diastema, they undergo apoptosis and regress to ensure that this region remains tooth-free" [https://en.wikipedia.org/wiki/Diastema, PMID:16890158, PMID:24495023]
Show

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / complex
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction






 

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